Genome‐Wide Profiling of H3K27ac Identifies TDO2 as a Pivotal Therapeutic Target in Metabolic Associated Steatohepatitis Liver Disease

Genome‐Wide Profiling of H3K27ac Identifies TDO2 as a Pivotal Therapeutic Target in Metabolic Associated Steatohepatitis Liver Disease

Abstract H3K27ac has been widely recognized as a representative epigenetic marker of active enhancer, while its regulatory mechanisms in pathogenesis of metabolic dysfunction‐associated steatotic liver disease (MASLD) remain elusive. Here, a genome‐wide comparative study on H3K27ac activities and tr...

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Main Authors: Yaling Zhu, Limeng Shang, Yunshu Tang, Qiushuang Li, Lin Ding, Yi Wang, Tiantian Zhang, Bin Xie, Jinhu Ma, Xinyu Li, Shuwen Chen, Xinrui Yi, Jin Peng, Youfeng Liang, Anyuan He, Hong Yan, Huaqing Zhu, Buchun Zhang, Yong Zhu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
H3K27ac
M1 polarization
MASLD
TDO2
YY1
Online Access:https://doi.org/10.1002/advs.202404224
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