HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms
Heat Shock Factor 1 (HSF1) is a major transcriptional factor regulating the heat shock response and has become a potential target for overcoming cancer chemoresistance. This review comprehensively examines HSF1’s role in chemoresistance and its potential as a therapeutic target in cancer. We explore...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1500880/full |
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| author | Shruti Ghai Rejina Shrestha Kuo-Hui Su |
| author_facet | Shruti Ghai Rejina Shrestha Kuo-Hui Su |
| author_sort | Shruti Ghai |
| collection | DOAJ |
| description | Heat Shock Factor 1 (HSF1) is a major transcriptional factor regulating the heat shock response and has become a potential target for overcoming cancer chemoresistance. This review comprehensively examines HSF1’s role in chemoresistance and its potential as a therapeutic target in cancer. We explore the complex, intricate mechanism that regulates the activation of HSF1, HSF1’s function in promoting resistance to chemotherapy, and the strategies used to manipulate HSF1 for therapeutic benefit. In addition, we discuss emerging research implicating HSF1’s roles in autophagy, apoptosis, DNA damage repair, drug efflux, and thus chemoresistance. This article highlights the significance of HSF1 in cancer chemoresistance and its potential as a target for enhancing cancer treatment efficacy. |
| format | Article |
| id | doaj-art-4e923c3f793f42678e161d75991fa7e6 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-4e923c3f793f42678e161d75991fa7e62025-01-09T06:10:38ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-01-011210.3389/fcell.2024.15008801500880HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanismsShruti GhaiRejina ShresthaKuo-Hui SuHeat Shock Factor 1 (HSF1) is a major transcriptional factor regulating the heat shock response and has become a potential target for overcoming cancer chemoresistance. This review comprehensively examines HSF1’s role in chemoresistance and its potential as a therapeutic target in cancer. We explore the complex, intricate mechanism that regulates the activation of HSF1, HSF1’s function in promoting resistance to chemotherapy, and the strategies used to manipulate HSF1 for therapeutic benefit. In addition, we discuss emerging research implicating HSF1’s roles in autophagy, apoptosis, DNA damage repair, drug efflux, and thus chemoresistance. This article highlights the significance of HSF1 in cancer chemoresistance and its potential as a target for enhancing cancer treatment efficacy.https://www.frontiersin.org/articles/10.3389/fcell.2024.1500880/fullheat shock factor 1chemoresistanceproteotoxic stress responseautophagyapoptosisdrug efflux |
| spellingShingle | Shruti Ghai Rejina Shrestha Kuo-Hui Su HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms Frontiers in Cell and Developmental Biology heat shock factor 1 chemoresistance proteotoxic stress response autophagy apoptosis drug efflux |
| title | HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms |
| title_full | HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms |
| title_fullStr | HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms |
| title_full_unstemmed | HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms |
| title_short | HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms |
| title_sort | hsf1 at the crossroads of chemoresistance from current insights to future horizons in cell death mechanisms |
| topic | heat shock factor 1 chemoresistance proteotoxic stress response autophagy apoptosis drug efflux |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1500880/full |
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