The impact of distal mutations on enzyme design is analogous to the allosteric regulation effect observed in effector binding or substrate transport within heterocomplexes. Building on this analogy, we employed molecular dynamics simulations to estimate the conformational landscape of enzymes and de...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Académie des sciences
2025-04-01
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| Series: | Comptes Rendus. Chimie |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.389/ |
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