Comparative Ten-Year Outcomes in Chronic and Acute Coronary Syndrome Patients Undergoing Invasive Diagnostics—Insights from the KORONEF Registry
Background: This study aimed to characterize acute coronary syndrome (ACS) patients undergoing invasive diagnostics and to evaluate prognostic factors for all-cause mortality over a 10-year follow-up period. Methods: The KORONEF study was a prospective, observational, single-center study that enroll...
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2024-11-01
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| author | Adam Kern Tomasz Stompór Krystian Bojko Ewa Sienkiewicz Sebastian Pawlak Krystyna Pawlak Dariusz Pawlak Grzegorz Poskrobko Ewa Andrasz Leszek Gromadziński Rakesh Jalali Dariusz Onichimowski Grażyna Piwko Artur Zalewski Jacek Bil |
| author_facet | Adam Kern Tomasz Stompór Krystian Bojko Ewa Sienkiewicz Sebastian Pawlak Krystyna Pawlak Dariusz Pawlak Grzegorz Poskrobko Ewa Andrasz Leszek Gromadziński Rakesh Jalali Dariusz Onichimowski Grażyna Piwko Artur Zalewski Jacek Bil |
| author_sort | Adam Kern |
| collection | DOAJ |
| description | Background: This study aimed to characterize acute coronary syndrome (ACS) patients undergoing invasive diagnostics and to evaluate prognostic factors for all-cause mortality over a 10-year follow-up period. Methods: The KORONEF study was a prospective, observational, single-center study that enrolled 492 patients, of whom 467 had confirmed coronary artery disease (CAD). Baseline demographic, clinical, laboratory, and procedural data were analyzed, focusing on the differences between ACS and chronic coronary syndrome (CCS) patients. Results: Males made up the majority of both the CCS and ACS groups (62.2% vs. 63.6%, <i>p</i> = 0.773), with no statistically significant difference in patient age between the CCS and ACS subpopulations (64.9 ± 9.5 vs. 63.7 ± 10.3, <i>p</i> = 0.106). The 10-year all-cause mortality was 29.8%, with no statistically significant difference between ACS and CCS patients. However, statistically significantly more patients with CCS underwent CABG in the follow-up than ACS patients (9.9% vs. 4.6%, <i>p</i> = 0.042). In a multivariable analysis, in the ACS subgroup, statistically significant predictors of all-cause mortality at 10 years included being between 75 and 90 years old (HR 4.99), not having had a previous stroke (HR 0.27), the absence of cardiac arrest (HR 0.20), and a left ventricular ejection fraction > 60% (HR 0.23). Conclusions: The long-term outcomes of the ACS patients highlight age and left ventricular function as significant prognostic factors, underscoring the importance of these parameters in risk stratification. |
| format | Article |
| id | doaj-art-4e402c9ae4e3432f8d26d7f9a49073c4 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-11-01 |
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| series | Biomedicines |
| spelling | doaj-art-4e402c9ae4e3432f8d26d7f9a49073c42024-12-27T14:12:29ZengMDPI AGBiomedicines2227-90592024-11-011212267210.3390/biomedicines12122672Comparative Ten-Year Outcomes in Chronic and Acute Coronary Syndrome Patients Undergoing Invasive Diagnostics—Insights from the KORONEF RegistryAdam Kern0Tomasz Stompór1Krystian Bojko2Ewa Sienkiewicz3Sebastian Pawlak4Krystyna Pawlak5Dariusz Pawlak6Grzegorz Poskrobko7Ewa Andrasz8Leszek Gromadziński9Rakesh Jalali10Dariusz Onichimowski11Grażyna Piwko12Artur Zalewski13Jacek Bil14Department of Cardiology and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-727 Olsztyn, PolandDepartment of Nephrology, Hypertension and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-727 Olsztyn, PolandDepartment of Cardiology and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-727 Olsztyn, PolandDepartment of Cardiology, Regional Specialist Hospital in Olsztyn, 10-045 Olsztyn, PolandDepartment of Cardiology and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-727 Olsztyn, PolandDepartment of Monitored Pharmacotherapy, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Pharmacodynamics, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Cardiology, Regional Specialist Hospital in Olsztyn, 10-045 Olsztyn, PolandDepartment of Cardiology, Regional Specialist Hospital in Olsztyn, 10-045 Olsztyn, PolandDepartment of Cardiology and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-727 Olsztyn, PolandDepartment of Emergency Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-727 Olsztyn, PolandDepartment of Anesthesiology and Intensive Care, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-727 Olsztyn, PolandDepartment of Cardiology, University of Warmia and Mazury in Olsztyn, Branch in Ełk, 19-300 Ełk, PolandScanmed Cardiology Center in Ełk, 19-300 Ełk, PolandNational Medical Institute of the Ministry of Interior and Administration, 02-507 Warsaw, PolandBackground: This study aimed to characterize acute coronary syndrome (ACS) patients undergoing invasive diagnostics and to evaluate prognostic factors for all-cause mortality over a 10-year follow-up period. Methods: The KORONEF study was a prospective, observational, single-center study that enrolled 492 patients, of whom 467 had confirmed coronary artery disease (CAD). Baseline demographic, clinical, laboratory, and procedural data were analyzed, focusing on the differences between ACS and chronic coronary syndrome (CCS) patients. Results: Males made up the majority of both the CCS and ACS groups (62.2% vs. 63.6%, <i>p</i> = 0.773), with no statistically significant difference in patient age between the CCS and ACS subpopulations (64.9 ± 9.5 vs. 63.7 ± 10.3, <i>p</i> = 0.106). The 10-year all-cause mortality was 29.8%, with no statistically significant difference between ACS and CCS patients. However, statistically significantly more patients with CCS underwent CABG in the follow-up than ACS patients (9.9% vs. 4.6%, <i>p</i> = 0.042). In a multivariable analysis, in the ACS subgroup, statistically significant predictors of all-cause mortality at 10 years included being between 75 and 90 years old (HR 4.99), not having had a previous stroke (HR 0.27), the absence of cardiac arrest (HR 0.20), and a left ventricular ejection fraction > 60% (HR 0.23). Conclusions: The long-term outcomes of the ACS patients highlight age and left ventricular function as significant prognostic factors, underscoring the importance of these parameters in risk stratification.https://www.mdpi.com/2227-9059/12/12/2672atherosclerosismortality predictorsinvasive angiographylong-term outcomes |
| spellingShingle | Adam Kern Tomasz Stompór Krystian Bojko Ewa Sienkiewicz Sebastian Pawlak Krystyna Pawlak Dariusz Pawlak Grzegorz Poskrobko Ewa Andrasz Leszek Gromadziński Rakesh Jalali Dariusz Onichimowski Grażyna Piwko Artur Zalewski Jacek Bil Comparative Ten-Year Outcomes in Chronic and Acute Coronary Syndrome Patients Undergoing Invasive Diagnostics—Insights from the KORONEF Registry Biomedicines atherosclerosis mortality predictors invasive angiography long-term outcomes |
| title | Comparative Ten-Year Outcomes in Chronic and Acute Coronary Syndrome Patients Undergoing Invasive Diagnostics—Insights from the KORONEF Registry |
| title_full | Comparative Ten-Year Outcomes in Chronic and Acute Coronary Syndrome Patients Undergoing Invasive Diagnostics—Insights from the KORONEF Registry |
| title_fullStr | Comparative Ten-Year Outcomes in Chronic and Acute Coronary Syndrome Patients Undergoing Invasive Diagnostics—Insights from the KORONEF Registry |
| title_full_unstemmed | Comparative Ten-Year Outcomes in Chronic and Acute Coronary Syndrome Patients Undergoing Invasive Diagnostics—Insights from the KORONEF Registry |
| title_short | Comparative Ten-Year Outcomes in Chronic and Acute Coronary Syndrome Patients Undergoing Invasive Diagnostics—Insights from the KORONEF Registry |
| title_sort | comparative ten year outcomes in chronic and acute coronary syndrome patients undergoing invasive diagnostics insights from the koronef registry |
| topic | atherosclerosis mortality predictors invasive angiography long-term outcomes |
| url | https://www.mdpi.com/2227-9059/12/12/2672 |
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