Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation
Summary: How a single, naive T cell can give rise to diverse progenies of effector and memory cells is not completely understood. One way to achieve this is by asymmetric cell division (ACD), characterized by an unequal distribution of cellular cargo, resulting in divergent daughter cells already af...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724014785 |
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| author | Niculò Barandun Benjamin Meier Gautier Stehli Fabienne Gräbnitz Nathan Zangger Annette Oxenius |
| author_facet | Niculò Barandun Benjamin Meier Gautier Stehli Fabienne Gräbnitz Nathan Zangger Annette Oxenius |
| author_sort | Niculò Barandun |
| collection | DOAJ |
| description | Summary: How a single, naive T cell can give rise to diverse progenies of effector and memory cells is not completely understood. One way to achieve this is by asymmetric cell division (ACD), characterized by an unequal distribution of cellular cargo, resulting in divergent daughter cells already after the first division—one being more destined to an effector and the other more to a memory fate. Here, we established two methods to analyze the relative distribution of the older “mother” centrosome and the younger “daughter” centrosome during the first cell division of activated CD8+ T cells. We show that upon ACD, the mother centrosome is inherited by the effector-like daughter cell in a ninein-dependent mechanism. Ninein deletion abolished this effect and led to impaired differentiation of memory-like daughter cells. These findings suggest that directed centrosome inheritance upon ACD has functional effects on the fate diversification of CD8+ T cells. |
| format | Article |
| id | doaj-art-4e32cf380a5c415da83f67ef41f69fb6 |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-4e32cf380a5c415da83f67ef41f69fb62025-01-07T04:17:19ZengElsevierCell Reports2211-12472025-01-01441115127Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formationNiculò Barandun0Benjamin Meier1Gautier Stehli2Fabienne Gräbnitz3Nathan Zangger4Annette Oxenius5Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, SwitzerlandInstitute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, SwitzerlandInstitute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, SwitzerlandInstitute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, SwitzerlandInstitute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, SwitzerlandInstitute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland; Corresponding authorSummary: How a single, naive T cell can give rise to diverse progenies of effector and memory cells is not completely understood. One way to achieve this is by asymmetric cell division (ACD), characterized by an unequal distribution of cellular cargo, resulting in divergent daughter cells already after the first division—one being more destined to an effector and the other more to a memory fate. Here, we established two methods to analyze the relative distribution of the older “mother” centrosome and the younger “daughter” centrosome during the first cell division of activated CD8+ T cells. We show that upon ACD, the mother centrosome is inherited by the effector-like daughter cell in a ninein-dependent mechanism. Ninein deletion abolished this effect and led to impaired differentiation of memory-like daughter cells. These findings suggest that directed centrosome inheritance upon ACD has functional effects on the fate diversification of CD8+ T cells.http://www.sciencedirect.com/science/article/pii/S2211124724014785CP: Immunology |
| spellingShingle | Niculò Barandun Benjamin Meier Gautier Stehli Fabienne Gräbnitz Nathan Zangger Annette Oxenius Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation Cell Reports CP: Immunology |
| title | Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation |
| title_full | Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation |
| title_fullStr | Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation |
| title_full_unstemmed | Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation |
| title_short | Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation |
| title_sort | targeted localization of the mother centrosome in cd8 t cells undergoing asymmetric cell division promotes memory formation |
| topic | CP: Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724014785 |
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