Pregnane X receptor activation promotes hematopoiesis during liver regeneration by inducing proliferation of hematopoietic stem and progenitor cells in mice

Pregnane X receptor activation promotes hematopoiesis during liver regeneration by inducing proliferation of hematopoietic stem and progenitor cells in mice

Liver regeneration is a complex process that involves the recruitment of bone marrow (BM)-derived hematopoietic stem and progenitor cells (HSPCs). Pregnane X receptor (PXR), also known as NR1I2, is an important regulator for liver enlargement and regeneration. However, the role of PXR activation in...

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Bibliographic Details
Main Authors: Shuang Hu, Chenghua Wu, Dan Li, Xiaowen Jiang, Peng Wang, Guofang Bi, Hui Ouyang, Fengting Liang, Wenhong Zhou, Xiao Yang, Jian-Hong Fang, Huichang Bi
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmacological Research
Subjects:
Pregnane X receptor
Hematopoietic stem and progenitor cells
Liver regeneration
Irradiation
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004493
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