Prevalence of hepatitis coinfection and substance use among antiretroviral therapy clinic clients with hazardous alcohol use in Vietnam.

The confluence of injection drug use (IDU), alcohol consumption, and viral hepatitis increases morbidity among persons living with HIV (PWH). We present a secondary analysis of a randomized controlled trial of alcohol reduction interventions in Thai Nguyen, Vietnam conducted between 2016-2018. We as...

Full description

Saved in:
Bibliographic Details
Main Authors: Jane S Chen, Sara N Levintow, Ha V Tran, Adams L Sibley, Natalie A Blackburn, Teerada Sripaipan, Heidi E Hutton, Vivian F Go, Geetanjali Chander
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLOS Global Public Health
Online Access:https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0003744&type=printable
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1841555234712715264
author Jane S Chen
Sara N Levintow
Ha V Tran
Adams L Sibley
Natalie A Blackburn
Teerada Sripaipan
Heidi E Hutton
Vivian F Go
Geetanjali Chander
author_facet Jane S Chen
Sara N Levintow
Ha V Tran
Adams L Sibley
Natalie A Blackburn
Teerada Sripaipan
Heidi E Hutton
Vivian F Go
Geetanjali Chander
author_sort Jane S Chen
collection DOAJ
description The confluence of injection drug use (IDU), alcohol consumption, and viral hepatitis increases morbidity among persons living with HIV (PWH). We present a secondary analysis of a randomized controlled trial of alcohol reduction interventions in Thai Nguyen, Vietnam conducted between 2016-2018. We assessed hepatitis B (HBV) and hepatitis C (HCV) coinfection among PWH reporting hazardous alcohol consumption and examined differences in IDU and alcohol use by coinfection status. Participants were ≥18 years old, living with HIV, and reported hazardous alcohol consumption per the WHO Alcohol Use Disorders Identification Test Consumption (AUDIT-C; score ≥4 for men, score ≥3 for women). At enrollment, participants were tested for hepatitis coinfection with HBV surface antigen tests and rapid serological HCV tests. Demographic information, IDU, and recent alcohol consumption were assessed via behavioral survey and 30-day timeline follow back. Fishers Exact and Kruskal-Wallis tests were used for statistical testing. Hepatitis coinfection was common among the 440 enrolled PWH: HCV: n = 355 (81%); HBV: n = 5 (1%); HBV and HCV: n = 37 (8%). Only 10% (n = 43) of participants had no hepatitis coinfection. Among those who tested positive for HBV, 36% had previously been diagnosed with HBV; among those who tested seropositive for HCV, 18% had previously received an HCV diagnosis. History of IDU was higher among those with hepatitis coinfection (HBV or HCV coinfection: 88%; HBV and HCV coinfections: 97%) than those without hepatitis coinfection (7%; p<0.01). Median days of alcohol consumption in the last 30 days was higher among those with coinfection (HBV or HCV coinfection: 20 (Interquartile Range (IQR): 10-30); HBV and HCV coinfections: 22 (IQR: 13-28) than those without hepatitis coinfection (10; IQR: 6-21; p<0.01). The syndemic conditions of HIV, hepatitis, IDU, and alcohol use are deeply entangled and challenging to parse out. Integrated health services are warranted to reduce the risk of liver-related morbidity.
format Article
id doaj-art-4dd7cd55e6a648edb23af55a9cd042bf
institution Kabale University
issn 2767-3375
language English
publishDate 2024-01-01
publisher Public Library of Science (PLoS)
record_format Article
series PLOS Global Public Health
spelling doaj-art-4dd7cd55e6a648edb23af55a9cd042bf2025-01-08T05:51:36ZengPublic Library of Science (PLoS)PLOS Global Public Health2767-33752024-01-01412e000374410.1371/journal.pgph.0003744Prevalence of hepatitis coinfection and substance use among antiretroviral therapy clinic clients with hazardous alcohol use in Vietnam.Jane S ChenSara N LevintowHa V TranAdams L SibleyNatalie A BlackburnTeerada SripaipanHeidi E HuttonVivian F GoGeetanjali ChanderThe confluence of injection drug use (IDU), alcohol consumption, and viral hepatitis increases morbidity among persons living with HIV (PWH). We present a secondary analysis of a randomized controlled trial of alcohol reduction interventions in Thai Nguyen, Vietnam conducted between 2016-2018. We assessed hepatitis B (HBV) and hepatitis C (HCV) coinfection among PWH reporting hazardous alcohol consumption and examined differences in IDU and alcohol use by coinfection status. Participants were ≥18 years old, living with HIV, and reported hazardous alcohol consumption per the WHO Alcohol Use Disorders Identification Test Consumption (AUDIT-C; score ≥4 for men, score ≥3 for women). At enrollment, participants were tested for hepatitis coinfection with HBV surface antigen tests and rapid serological HCV tests. Demographic information, IDU, and recent alcohol consumption were assessed via behavioral survey and 30-day timeline follow back. Fishers Exact and Kruskal-Wallis tests were used for statistical testing. Hepatitis coinfection was common among the 440 enrolled PWH: HCV: n = 355 (81%); HBV: n = 5 (1%); HBV and HCV: n = 37 (8%). Only 10% (n = 43) of participants had no hepatitis coinfection. Among those who tested positive for HBV, 36% had previously been diagnosed with HBV; among those who tested seropositive for HCV, 18% had previously received an HCV diagnosis. History of IDU was higher among those with hepatitis coinfection (HBV or HCV coinfection: 88%; HBV and HCV coinfections: 97%) than those without hepatitis coinfection (7%; p<0.01). Median days of alcohol consumption in the last 30 days was higher among those with coinfection (HBV or HCV coinfection: 20 (Interquartile Range (IQR): 10-30); HBV and HCV coinfections: 22 (IQR: 13-28) than those without hepatitis coinfection (10; IQR: 6-21; p<0.01). The syndemic conditions of HIV, hepatitis, IDU, and alcohol use are deeply entangled and challenging to parse out. Integrated health services are warranted to reduce the risk of liver-related morbidity.https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0003744&type=printable
spellingShingle Jane S Chen
Sara N Levintow
Ha V Tran
Adams L Sibley
Natalie A Blackburn
Teerada Sripaipan
Heidi E Hutton
Vivian F Go
Geetanjali Chander
Prevalence of hepatitis coinfection and substance use among antiretroviral therapy clinic clients with hazardous alcohol use in Vietnam.
PLOS Global Public Health
title Prevalence of hepatitis coinfection and substance use among antiretroviral therapy clinic clients with hazardous alcohol use in Vietnam.
title_full Prevalence of hepatitis coinfection and substance use among antiretroviral therapy clinic clients with hazardous alcohol use in Vietnam.
title_fullStr Prevalence of hepatitis coinfection and substance use among antiretroviral therapy clinic clients with hazardous alcohol use in Vietnam.
title_full_unstemmed Prevalence of hepatitis coinfection and substance use among antiretroviral therapy clinic clients with hazardous alcohol use in Vietnam.
title_short Prevalence of hepatitis coinfection and substance use among antiretroviral therapy clinic clients with hazardous alcohol use in Vietnam.
title_sort prevalence of hepatitis coinfection and substance use among antiretroviral therapy clinic clients with hazardous alcohol use in vietnam
url https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0003744&type=printable
work_keys_str_mv AT janeschen prevalenceofhepatitiscoinfectionandsubstanceuseamongantiretroviraltherapyclinicclientswithhazardousalcoholuseinvietnam
AT saranlevintow prevalenceofhepatitiscoinfectionandsubstanceuseamongantiretroviraltherapyclinicclientswithhazardousalcoholuseinvietnam
AT havtran prevalenceofhepatitiscoinfectionandsubstanceuseamongantiretroviraltherapyclinicclientswithhazardousalcoholuseinvietnam
AT adamslsibley prevalenceofhepatitiscoinfectionandsubstanceuseamongantiretroviraltherapyclinicclientswithhazardousalcoholuseinvietnam
AT natalieablackburn prevalenceofhepatitiscoinfectionandsubstanceuseamongantiretroviraltherapyclinicclientswithhazardousalcoholuseinvietnam
AT teeradasripaipan prevalenceofhepatitiscoinfectionandsubstanceuseamongantiretroviraltherapyclinicclientswithhazardousalcoholuseinvietnam
AT heidiehutton prevalenceofhepatitiscoinfectionandsubstanceuseamongantiretroviraltherapyclinicclientswithhazardousalcoholuseinvietnam
AT vivianfgo prevalenceofhepatitiscoinfectionandsubstanceuseamongantiretroviraltherapyclinicclientswithhazardousalcoholuseinvietnam
AT geetanjalichander prevalenceofhepatitiscoinfectionandsubstanceuseamongantiretroviraltherapyclinicclientswithhazardousalcoholuseinvietnam