Mammary myofibroblastoma with unusual morphological and immunohistochemical features
Mammary myofibroblastoma (MFB) is a rare mesenchymal tumor, derived from mammary stromal fibro/myofibroblasts, which has various morphological features and characteristic immunohistochemical staining. The epithelioid morphologic variant is defined, accordingly, as a proliferation of exclusively or p...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2017-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=2;spage=223;epage=225;aulast=Boudaouara |
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| _version_ | 1849767986311725056 |
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| author | Ons Boudaouara Chiraz Chaari Abdelkhalek Hassini Tahya Sellami Boudaouara |
| author_facet | Ons Boudaouara Chiraz Chaari Abdelkhalek Hassini Tahya Sellami Boudaouara |
| author_sort | Ons Boudaouara |
| collection | DOAJ |
| description | Mammary myofibroblastoma (MFB) is a rare mesenchymal tumor, derived from mammary stromal fibro/myofibroblasts, which has various morphological features and characteristic immunohistochemical staining. The epithelioid morphologic variant is defined, accordingly, as a proliferation of exclusively or predominantly (>50%) epithelioid cells, variably embedded in a myxoid to fibrous stroma. These histological and cytological features may pose a diagnostic challenge mainly with metaplastic carcinoma and invasive lobular carcinoma of the breast. Thus, immunohistochemical staining by myofibroblastic markers is helpful for confirming diagnosis. Herein, we present a case of MFB in a 43-year-old female. This case report emphasizes the role of immunohistochemistry as gold standard in the diagnosis of MFB. This case is also being presented because of its unusual radiologic findings, its epithelioid histologic variant mimicking malignancy, and its uncommon immunohistochemical phenotype. |
| format | Article |
| id | doaj-art-4dd114e4e4fd4d8faeedf5de67b3b51e |
| institution | DOAJ |
| issn | 0971-5851 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-4dd114e4e4fd4d8faeedf5de67b3b51e2025-08-20T03:03:59ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512017-01-0138222322510.4103/ijmpo.ijmpo_115_16Mammary myofibroblastoma with unusual morphological and immunohistochemical featuresOns BoudaouaraChiraz ChaariAbdelkhalek HassiniTahya Sellami BoudaouaraMammary myofibroblastoma (MFB) is a rare mesenchymal tumor, derived from mammary stromal fibro/myofibroblasts, which has various morphological features and characteristic immunohistochemical staining. The epithelioid morphologic variant is defined, accordingly, as a proliferation of exclusively or predominantly (>50%) epithelioid cells, variably embedded in a myxoid to fibrous stroma. These histological and cytological features may pose a diagnostic challenge mainly with metaplastic carcinoma and invasive lobular carcinoma of the breast. Thus, immunohistochemical staining by myofibroblastic markers is helpful for confirming diagnosis. Herein, we present a case of MFB in a 43-year-old female. This case report emphasizes the role of immunohistochemistry as gold standard in the diagnosis of MFB. This case is also being presented because of its unusual radiologic findings, its epithelioid histologic variant mimicking malignancy, and its uncommon immunohistochemical phenotype.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=2;spage=223;epage=225;aulast=BoudaouaraBreast neoplasmsdiagnosisimmunohistochemistrymyofibroblastomastaining and labeling |
| spellingShingle | Ons Boudaouara Chiraz Chaari Abdelkhalek Hassini Tahya Sellami Boudaouara Mammary myofibroblastoma with unusual morphological and immunohistochemical features Indian Journal of Medical and Paediatric Oncology Breast neoplasms diagnosis immunohistochemistry myofibroblastoma staining and labeling |
| title | Mammary myofibroblastoma with unusual morphological and immunohistochemical features |
| title_full | Mammary myofibroblastoma with unusual morphological and immunohistochemical features |
| title_fullStr | Mammary myofibroblastoma with unusual morphological and immunohistochemical features |
| title_full_unstemmed | Mammary myofibroblastoma with unusual morphological and immunohistochemical features |
| title_short | Mammary myofibroblastoma with unusual morphological and immunohistochemical features |
| title_sort | mammary myofibroblastoma with unusual morphological and immunohistochemical features |
| topic | Breast neoplasms diagnosis immunohistochemistry myofibroblastoma staining and labeling |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=2;spage=223;epage=225;aulast=Boudaouara |
| work_keys_str_mv | AT onsboudaouara mammarymyofibroblastomawithunusualmorphologicalandimmunohistochemicalfeatures AT chirazchaari mammarymyofibroblastomawithunusualmorphologicalandimmunohistochemicalfeatures AT abdelkhalekhassini mammarymyofibroblastomawithunusualmorphologicalandimmunohistochemicalfeatures AT tahyasellamiboudaouara mammarymyofibroblastomawithunusualmorphologicalandimmunohistochemicalfeatures |