The Effects of Krill Oil on mTOR Signaling and Resistance Exercise: A Pilot Study
Introduction. Krill oil supplementation has been shown to improve postexercise immune function; however, its effect on muscle hypertrophy is currently unknown. Therefore, the aim of present study was to investigate the ability of krill oil to stimulate mTOR signaling and its ability to augment resis...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2018/7625981 |
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| author | John Georges Matthew H. Sharp Ryan P. Lowery Jacob M. Wilson Martin Purpura Troy A. Hornberger Flint Harding James H. Johnson David M. Peele Ralf Jäger |
| author_facet | John Georges Matthew H. Sharp Ryan P. Lowery Jacob M. Wilson Martin Purpura Troy A. Hornberger Flint Harding James H. Johnson David M. Peele Ralf Jäger |
| author_sort | John Georges |
| collection | DOAJ |
| description | Introduction. Krill oil supplementation has been shown to improve postexercise immune function; however, its effect on muscle hypertrophy is currently unknown. Therefore, the aim of present study was to investigate the ability of krill oil to stimulate mTOR signaling and its ability to augment resistance training-induced changes in body composition and performance. Methods. C2C12 myoblasts cells were stimulated with krill oil or soy-derived phosphatidylcholine (S-PC), and then, the ratio of P-p70-389 to total p70 was used as readout for mTOR signaling. In double-blind,placebo-controlled study, resistance trained subjects consumed either 3 g krill oil daily or placebo, and each took part in an 8-week periodized resistance training program. Body composition, maximal strength, peak power, and rate of perceived recovery were assessed collectively at the end of weeks 0 and 8. In addition, safety parameters (comprehensive metabolic panel (CMP), complete blood count (CBC), and urine analysis (UA)) and cognitive performance were measured pre- and posttesting. Results. Krill oil significantly stimulated mTOR signaling in comparison to S-PC and control. No differences for markers on the CMP, CBC, or UA were observed. Krill oil significantly increased lean body mass from baseline (p=0.021, 1.4 kg, +2.1%); however, there were no statistically significant differences between groups for any measures taken. Conclusion. Krill oil activates mTOR signaling. Krill oil supplementation in athletes is safe, and its effect on resistance exercise deserves further research. |
| format | Article |
| id | doaj-art-4db5d2a109db4245a1d16387a3f64306 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-4db5d2a109db4245a1d16387a3f643062025-02-03T05:47:48ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322018-01-01201810.1155/2018/76259817625981The Effects of Krill Oil on mTOR Signaling and Resistance Exercise: A Pilot StudyJohn Georges0Matthew H. Sharp1Ryan P. Lowery2Jacob M. Wilson3Martin Purpura4Troy A. Hornberger5Flint Harding6James H. Johnson7David M. Peele8Ralf Jäger9Applied Science and Performance Institute, 5850 W. Cypress St., Tampa, FL 33607, USAApplied Science and Performance Institute, 5850 W. Cypress St., Tampa, FL 33607, USAApplied Science and Performance Institute, 5850 W. Cypress St., Tampa, FL 33607, USAApplied Science and Performance Institute, 5850 W. Cypress St., Tampa, FL 33607, USAIncrenovo LLC, 2138 E. Lafayette Pl, Milwaukee, WI 53202, USADepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USAAvoca Inc., 841 Avoca Farm Rd., Merry Hill, NC 27957, USAAvoca Inc., 841 Avoca Farm Rd., Merry Hill, NC 27957, USAAvoca Inc., 841 Avoca Farm Rd., Merry Hill, NC 27957, USAIncrenovo LLC, 2138 E. Lafayette Pl, Milwaukee, WI 53202, USAIntroduction. Krill oil supplementation has been shown to improve postexercise immune function; however, its effect on muscle hypertrophy is currently unknown. Therefore, the aim of present study was to investigate the ability of krill oil to stimulate mTOR signaling and its ability to augment resistance training-induced changes in body composition and performance. Methods. C2C12 myoblasts cells were stimulated with krill oil or soy-derived phosphatidylcholine (S-PC), and then, the ratio of P-p70-389 to total p70 was used as readout for mTOR signaling. In double-blind,placebo-controlled study, resistance trained subjects consumed either 3 g krill oil daily or placebo, and each took part in an 8-week periodized resistance training program. Body composition, maximal strength, peak power, and rate of perceived recovery were assessed collectively at the end of weeks 0 and 8. In addition, safety parameters (comprehensive metabolic panel (CMP), complete blood count (CBC), and urine analysis (UA)) and cognitive performance were measured pre- and posttesting. Results. Krill oil significantly stimulated mTOR signaling in comparison to S-PC and control. No differences for markers on the CMP, CBC, or UA were observed. Krill oil significantly increased lean body mass from baseline (p=0.021, 1.4 kg, +2.1%); however, there were no statistically significant differences between groups for any measures taken. Conclusion. Krill oil activates mTOR signaling. Krill oil supplementation in athletes is safe, and its effect on resistance exercise deserves further research.http://dx.doi.org/10.1155/2018/7625981 |
| spellingShingle | John Georges Matthew H. Sharp Ryan P. Lowery Jacob M. Wilson Martin Purpura Troy A. Hornberger Flint Harding James H. Johnson David M. Peele Ralf Jäger The Effects of Krill Oil on mTOR Signaling and Resistance Exercise: A Pilot Study Journal of Nutrition and Metabolism |
| title | The Effects of Krill Oil on mTOR Signaling and Resistance Exercise: A Pilot Study |
| title_full | The Effects of Krill Oil on mTOR Signaling and Resistance Exercise: A Pilot Study |
| title_fullStr | The Effects of Krill Oil on mTOR Signaling and Resistance Exercise: A Pilot Study |
| title_full_unstemmed | The Effects of Krill Oil on mTOR Signaling and Resistance Exercise: A Pilot Study |
| title_short | The Effects of Krill Oil on mTOR Signaling and Resistance Exercise: A Pilot Study |
| title_sort | effects of krill oil on mtor signaling and resistance exercise a pilot study |
| url | http://dx.doi.org/10.1155/2018/7625981 |
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