Multiorgan-dysfunction Secondary to Glyphosate Poisoning: A Case Report
Globally, glyphosate is the most widely used non selective broad-spectrum herbicide. The uncoupling of oxidative phosphorylation and polyoxymethylene amine-mediated cardiotoxicity are thought to contribute to glyphosate toxicity. Hereby, the authors presents a case report of 54-year-old male with an...
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| Language: | English |
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JCDR Research and Publications Private Limited
2024-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/20261/73158_CE[Ra1]_F(SS)_QC(AKA_IS)_PF1(VD_IS_SS)_PFA_NC(KM)_PN(KM).pdf |
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| author | Pujitha Karlapudi Viswanathan Pandurangan Devasena Srinivasan Divya Joyce |
| author_facet | Pujitha Karlapudi Viswanathan Pandurangan Devasena Srinivasan Divya Joyce |
| author_sort | Pujitha Karlapudi |
| collection | DOAJ |
| description | Globally, glyphosate is the most widely used non selective broad-spectrum herbicide. The uncoupling of oxidative phosphorylation and polyoxymethylene amine-mediated cardiotoxicity are thought to contribute to glyphosate toxicity. Hereby, the authors presents a case report of 54-year-old male with an alleged history of consuming glyphosate, who experienced complications 48-72 hours after ingestion. These complications included acute kidney injury, corrosive injury to the oesophageal mucosa, cardiotoxicity, and Acute Respiratory Distress Syndrome (ARDS). These are rare but severe manifestations of oral glyphosate-Polyoxyethyleneamine (POEA) poisoning. The patient survived due to aggressive supportive therapy, which included renal replacement therapy, non invasive ventilation, and heart failure management. Since, there is no antidote for glyphosate poisoning, exposure to glyphosate can be fatal, necessitating vigorous supportive therapy. Published data indicate that the use of additional therapies, such as intravenous (i.v.) fat emulsion (20% intralipid, 100 mL) and adsorption haemoperfusion cartridge filters, has had limited success. |
| format | Article |
| id | doaj-art-4d565852b53d4b088b91fd3b51bed972 |
| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-4d565852b53d4b088b91fd3b51bed9722024-11-16T11:57:48ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2024-11-011811010310.7860/JCDR/2024/73158.20261Multiorgan-dysfunction Secondary to Glyphosate Poisoning: A Case ReportPujitha Karlapudi0Viswanathan Pandurangan1Devasena Srinivasan2Divya Joyce3Junior Resident, Department of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Kanchipuram, Tamil Nadu, India.Associate Professor, Department of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Kanchipuram, Tamil Nadu, India.Professor, Department of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Kanchipuram, Tamil Nadu, India.Assistant Professor, Department of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Kanchipuram, Tamil Nadu, India.Globally, glyphosate is the most widely used non selective broad-spectrum herbicide. The uncoupling of oxidative phosphorylation and polyoxymethylene amine-mediated cardiotoxicity are thought to contribute to glyphosate toxicity. Hereby, the authors presents a case report of 54-year-old male with an alleged history of consuming glyphosate, who experienced complications 48-72 hours after ingestion. These complications included acute kidney injury, corrosive injury to the oesophageal mucosa, cardiotoxicity, and Acute Respiratory Distress Syndrome (ARDS). These are rare but severe manifestations of oral glyphosate-Polyoxyethyleneamine (POEA) poisoning. The patient survived due to aggressive supportive therapy, which included renal replacement therapy, non invasive ventilation, and heart failure management. Since, there is no antidote for glyphosate poisoning, exposure to glyphosate can be fatal, necessitating vigorous supportive therapy. Published data indicate that the use of additional therapies, such as intravenous (i.v.) fat emulsion (20% intralipid, 100 mL) and adsorption haemoperfusion cartridge filters, has had limited success.https://www.jcdr.net/articles/PDF/20261/73158_CE[Ra1]_F(SS)_QC(AKA_IS)_PF1(VD_IS_SS)_PFA_NC(KM)_PN(KM).pdfacute renal failureherbicideorganophosphatespolyoxyethyleneamine |
| spellingShingle | Pujitha Karlapudi Viswanathan Pandurangan Devasena Srinivasan Divya Joyce Multiorgan-dysfunction Secondary to Glyphosate Poisoning: A Case Report Journal of Clinical and Diagnostic Research acute renal failure herbicide organophosphates polyoxyethyleneamine |
| title | Multiorgan-dysfunction Secondary to Glyphosate Poisoning: A Case Report |
| title_full | Multiorgan-dysfunction Secondary to Glyphosate Poisoning: A Case Report |
| title_fullStr | Multiorgan-dysfunction Secondary to Glyphosate Poisoning: A Case Report |
| title_full_unstemmed | Multiorgan-dysfunction Secondary to Glyphosate Poisoning: A Case Report |
| title_short | Multiorgan-dysfunction Secondary to Glyphosate Poisoning: A Case Report |
| title_sort | multiorgan dysfunction secondary to glyphosate poisoning a case report |
| topic | acute renal failure herbicide organophosphates polyoxyethyleneamine |
| url | https://www.jcdr.net/articles/PDF/20261/73158_CE[Ra1]_F(SS)_QC(AKA_IS)_PF1(VD_IS_SS)_PFA_NC(KM)_PN(KM).pdf |
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