Innovative Nanomedicine Delivery: Targeting Tumor Microenvironment to Defeat Drug Resistance
Nanodrug delivery systems have revolutionized tumor therapy like never before. By overcoming the complexity of the tumor microenvironment (TME) and bypassing drug resistance mechanisms, nanotechnology has shown great potential to improve drug efficacy and reduce toxic side effects. This review exami...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/12/1549 |
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| author | Wenjun Meng Li Huang Jiamin Guo Qing Xin Jiyan Liu Yuzhu Hu |
| author_facet | Wenjun Meng Li Huang Jiamin Guo Qing Xin Jiyan Liu Yuzhu Hu |
| author_sort | Wenjun Meng |
| collection | DOAJ |
| description | Nanodrug delivery systems have revolutionized tumor therapy like never before. By overcoming the complexity of the tumor microenvironment (TME) and bypassing drug resistance mechanisms, nanotechnology has shown great potential to improve drug efficacy and reduce toxic side effects. This review examines the impact of the TME on drug resistance and recent advances in nanomedicine delivery systems to overcome this challenge. Characteristics of the TME such as hypoxia, acidity, and high interstitial pressure significantly reduce the effectiveness of chemotherapy and radiotherapy, leading to increased drug resistance in tumor cells. Then, this review summarizes innovative nanocarrier designs for these microenvironmental features, including hypoxia-sensitive nanoparticles, pH-responsive carriers, and multifunctional nanosystems that enable targeted drug release and improved drug penetration and accumulation in tumors. By combining nanotechnology with therapeutic strategies, this review offers a novel perspective by focusing on the innovative design of nanocarriers that interact with the TME, a dimension often overlooked in similar reviews. We highlight the dual role of these nanocarriers in therapeutic delivery and TME modulation, emphasize their potential to overcome drug resistance, and look at future research directions. |
| format | Article |
| id | doaj-art-4d410a8be0fc4fd2ae3ebae2a9fffb6a |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-4d410a8be0fc4fd2ae3ebae2a9fffb6a2024-12-27T14:46:28ZengMDPI AGPharmaceutics1999-49232024-12-011612154910.3390/pharmaceutics16121549Innovative Nanomedicine Delivery: Targeting Tumor Microenvironment to Defeat Drug ResistanceWenjun Meng0Li Huang1Jiamin Guo2Qing Xin3Jiyan Liu4Yuzhu Hu5Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaDivision of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaNanodrug delivery systems have revolutionized tumor therapy like never before. By overcoming the complexity of the tumor microenvironment (TME) and bypassing drug resistance mechanisms, nanotechnology has shown great potential to improve drug efficacy and reduce toxic side effects. This review examines the impact of the TME on drug resistance and recent advances in nanomedicine delivery systems to overcome this challenge. Characteristics of the TME such as hypoxia, acidity, and high interstitial pressure significantly reduce the effectiveness of chemotherapy and radiotherapy, leading to increased drug resistance in tumor cells. Then, this review summarizes innovative nanocarrier designs for these microenvironmental features, including hypoxia-sensitive nanoparticles, pH-responsive carriers, and multifunctional nanosystems that enable targeted drug release and improved drug penetration and accumulation in tumors. By combining nanotechnology with therapeutic strategies, this review offers a novel perspective by focusing on the innovative design of nanocarriers that interact with the TME, a dimension often overlooked in similar reviews. We highlight the dual role of these nanocarriers in therapeutic delivery and TME modulation, emphasize their potential to overcome drug resistance, and look at future research directions.https://www.mdpi.com/1999-4923/16/12/1549nanomedicine deliverytumor microenvironmentdrug resistance |
| spellingShingle | Wenjun Meng Li Huang Jiamin Guo Qing Xin Jiyan Liu Yuzhu Hu Innovative Nanomedicine Delivery: Targeting Tumor Microenvironment to Defeat Drug Resistance Pharmaceutics nanomedicine delivery tumor microenvironment drug resistance |
| title | Innovative Nanomedicine Delivery: Targeting Tumor Microenvironment to Defeat Drug Resistance |
| title_full | Innovative Nanomedicine Delivery: Targeting Tumor Microenvironment to Defeat Drug Resistance |
| title_fullStr | Innovative Nanomedicine Delivery: Targeting Tumor Microenvironment to Defeat Drug Resistance |
| title_full_unstemmed | Innovative Nanomedicine Delivery: Targeting Tumor Microenvironment to Defeat Drug Resistance |
| title_short | Innovative Nanomedicine Delivery: Targeting Tumor Microenvironment to Defeat Drug Resistance |
| title_sort | innovative nanomedicine delivery targeting tumor microenvironment to defeat drug resistance |
| topic | nanomedicine delivery tumor microenvironment drug resistance |
| url | https://www.mdpi.com/1999-4923/16/12/1549 |
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