Genetic confounds of transgenerational epigenetic inheritance in mice
Transgenerational epigenetic inheritance in mammals remains a controversial phenomenon. A recent study by Takahashi et al. provides evidence for this mode of inheritance in mice by using a CRISPR/Cas9-based epigenetic editing technique to modify DNA methylation levels at specific promoters and then...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Epigenetics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15592294.2024.2318519 |
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| author | Daniel M. Sapozhnikov Moshe Szyf |
| author_facet | Daniel M. Sapozhnikov Moshe Szyf |
| author_sort | Daniel M. Sapozhnikov |
| collection | DOAJ |
| description | Transgenerational epigenetic inheritance in mammals remains a controversial phenomenon. A recent study by Takahashi et al. provides evidence for this mode of inheritance in mice by using a CRISPR/Cas9-based epigenetic editing technique to modify DNA methylation levels at specific promoters and then demonstrating the inheritance of the gain in methylation in offspring. In this technical commentary, we argue that the method used in the original study inherently amplifies the likelihood of genetic changes that thereafter lead to the heritability of epigenetic changes. We provide evidence that genetic changes from multiple sources do indeed occur in these experiments and explore several avenues by which these changes could be causal to the apparent inheritance of epigenetic changes. We conclude a genetic basis of inheritance cannot be ruled out and thus transgenerational epigenetic inheritance has not been adequately established by the original study. |
| format | Article |
| id | doaj-art-4d383914f15e48b3a9642ed8b465d9f0 |
| institution | Kabale University |
| issn | 1559-2294 1559-2308 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj-art-4d383914f15e48b3a9642ed8b465d9f02024-12-09T07:21:36ZengTaylor & Francis GroupEpigenetics1559-22941559-23082024-12-0119110.1080/15592294.2024.2318519Genetic confounds of transgenerational epigenetic inheritance in miceDaniel M. Sapozhnikov0Moshe Szyf1Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, CanadaDepartment of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, CanadaTransgenerational epigenetic inheritance in mammals remains a controversial phenomenon. A recent study by Takahashi et al. provides evidence for this mode of inheritance in mice by using a CRISPR/Cas9-based epigenetic editing technique to modify DNA methylation levels at specific promoters and then demonstrating the inheritance of the gain in methylation in offspring. In this technical commentary, we argue that the method used in the original study inherently amplifies the likelihood of genetic changes that thereafter lead to the heritability of epigenetic changes. We provide evidence that genetic changes from multiple sources do indeed occur in these experiments and explore several avenues by which these changes could be causal to the apparent inheritance of epigenetic changes. We conclude a genetic basis of inheritance cannot be ruled out and thus transgenerational epigenetic inheritance has not been adequately established by the original study.https://www.tandfonline.com/doi/10.1080/15592294.2024.2318519Epigeneticstransgenerational epigeneticsinheritancegeneticsmammalstransgenerational epigenetic inheritance |
| spellingShingle | Daniel M. Sapozhnikov Moshe Szyf Genetic confounds of transgenerational epigenetic inheritance in mice Epigenetics Epigenetics transgenerational epigenetics inheritance genetics mammals transgenerational epigenetic inheritance |
| title | Genetic confounds of transgenerational epigenetic inheritance in mice |
| title_full | Genetic confounds of transgenerational epigenetic inheritance in mice |
| title_fullStr | Genetic confounds of transgenerational epigenetic inheritance in mice |
| title_full_unstemmed | Genetic confounds of transgenerational epigenetic inheritance in mice |
| title_short | Genetic confounds of transgenerational epigenetic inheritance in mice |
| title_sort | genetic confounds of transgenerational epigenetic inheritance in mice |
| topic | Epigenetics transgenerational epigenetics inheritance genetics mammals transgenerational epigenetic inheritance |
| url | https://www.tandfonline.com/doi/10.1080/15592294.2024.2318519 |
| work_keys_str_mv | AT danielmsapozhnikov geneticconfoundsoftransgenerationalepigeneticinheritanceinmice AT mosheszyf geneticconfoundsoftransgenerationalepigeneticinheritanceinmice |