Nebulized dexmedetomidine in the treatment of obstetric post-dural puncture headache: two case reports
Abstract Post-dural puncture headache (PDPH) is a debilitating complication of neuraxial anesthesia, particularly prevalent in obstetric patients, usually characterized by a postural headache. PDPH is hypothesized to result from cerebrospinal fluid leakage through a dural puncture, triggering sympto...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-025-02896-4 |
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| author | Jeffrey Thomas Leonard J. Soloniuk Chris Mehdizadeh Peter Cheng Ashish Sinha |
| author_facet | Jeffrey Thomas Leonard J. Soloniuk Chris Mehdizadeh Peter Cheng Ashish Sinha |
| author_sort | Jeffrey Thomas |
| collection | DOAJ |
| description | Abstract Post-dural puncture headache (PDPH) is a debilitating complication of neuraxial anesthesia, particularly prevalent in obstetric patients, usually characterized by a postural headache. PDPH is hypothesized to result from cerebrospinal fluid leakage through a dural puncture, triggering symptoms like neck stiffness and subjective hearing changes. While conservative measures are common for treatment, more refractory cases may require invasive interventions such as an epidural blood patch (EBP). Recent studies have shown promise in using nebulized dexmedetomidine (nDEX) for PDPH, offering a non-invasive alternative to EBP. Two case presentations illustrate the efficacy of nDEX in resolving PDPH symptoms rapidly and completely. These cases underscore the need for exploring novel therapeutic options, especially in obstetric patients where safe and prompt relief is essential for maternal and newborn well-being. While the EBP remains the gold standard, its limitations of accessibility and invasiveness highlight the significance of investigating alternatives like nDEX. |
| format | Article |
| id | doaj-art-4d305b6d74b54614a4ef6ecabafaf6c9 |
| institution | Kabale University |
| issn | 1471-2253 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj-art-4d305b6d74b54614a4ef6ecabafaf6c92025-01-12T12:36:58ZengBMCBMC Anesthesiology1471-22532025-01-012511410.1186/s12871-025-02896-4Nebulized dexmedetomidine in the treatment of obstetric post-dural puncture headache: two case reportsJeffrey Thomas0Leonard J. Soloniuk1Chris Mehdizadeh2Peter Cheng3Ashish Sinha4Department of Anesthesiology and Perioperative Medicine, Riverside University Health SystemsDepartment of Anesthesiology and Perioperative Medicine, Riverside University Health SystemsUniversity of California Riverside School of MedicineDepartment of Anesthesiology and Perioperative Medicine, Riverside University Health SystemsDepartment of Anesthesiology, Loma Linda University Medical CenterAbstract Post-dural puncture headache (PDPH) is a debilitating complication of neuraxial anesthesia, particularly prevalent in obstetric patients, usually characterized by a postural headache. PDPH is hypothesized to result from cerebrospinal fluid leakage through a dural puncture, triggering symptoms like neck stiffness and subjective hearing changes. While conservative measures are common for treatment, more refractory cases may require invasive interventions such as an epidural blood patch (EBP). Recent studies have shown promise in using nebulized dexmedetomidine (nDEX) for PDPH, offering a non-invasive alternative to EBP. Two case presentations illustrate the efficacy of nDEX in resolving PDPH symptoms rapidly and completely. These cases underscore the need for exploring novel therapeutic options, especially in obstetric patients where safe and prompt relief is essential for maternal and newborn well-being. While the EBP remains the gold standard, its limitations of accessibility and invasiveness highlight the significance of investigating alternatives like nDEX.https://doi.org/10.1186/s12871-025-02896-4Obstetric post-dural puncture headache (PDPH)Obstetric anesthesiaNeuraxial anesthesiaDexmedetomidineCesarean deliveryCase report |
| spellingShingle | Jeffrey Thomas Leonard J. Soloniuk Chris Mehdizadeh Peter Cheng Ashish Sinha Nebulized dexmedetomidine in the treatment of obstetric post-dural puncture headache: two case reports BMC Anesthesiology Obstetric post-dural puncture headache (PDPH) Obstetric anesthesia Neuraxial anesthesia Dexmedetomidine Cesarean delivery Case report |
| title | Nebulized dexmedetomidine in the treatment of obstetric post-dural puncture headache: two case reports |
| title_full | Nebulized dexmedetomidine in the treatment of obstetric post-dural puncture headache: two case reports |
| title_fullStr | Nebulized dexmedetomidine in the treatment of obstetric post-dural puncture headache: two case reports |
| title_full_unstemmed | Nebulized dexmedetomidine in the treatment of obstetric post-dural puncture headache: two case reports |
| title_short | Nebulized dexmedetomidine in the treatment of obstetric post-dural puncture headache: two case reports |
| title_sort | nebulized dexmedetomidine in the treatment of obstetric post dural puncture headache two case reports |
| topic | Obstetric post-dural puncture headache (PDPH) Obstetric anesthesia Neuraxial anesthesia Dexmedetomidine Cesarean delivery Case report |
| url | https://doi.org/10.1186/s12871-025-02896-4 |
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