Erythema nodosum followed by eosinophilic pneumonia as an adverse effect of dupilumab treatment in a patient with severe asthma
Dupilumab is a monoclonal antibody that has recently been introduced for the treatment of asthma. It has the potential to significantly alter the progression and severity of T2 -dependent diseases, including severe asthma. However, dupilumab can cause transient hypereosinophilia. In rare cases, hype...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Respiratory Medicine Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221300712400159X |
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| author | Agnieszka Gawlewicz-Mroczka Marek Przybyszowski Grażyna Bochenek Maria Mroczka Krzysztof Sładek |
| author_facet | Agnieszka Gawlewicz-Mroczka Marek Przybyszowski Grażyna Bochenek Maria Mroczka Krzysztof Sładek |
| author_sort | Agnieszka Gawlewicz-Mroczka |
| collection | DOAJ |
| description | Dupilumab is a monoclonal antibody that has recently been introduced for the treatment of asthma. It has the potential to significantly alter the progression and severity of T2 -dependent diseases, including severe asthma. However, dupilumab can cause transient hypereosinophilia. In rare cases, hypereosinophilia can reach high levels and manifest with clinical symptoms. We present the case of a female patient who presented with hypereosinophilia of almost 5000 cells/μL accompanied by erythema nodosum during dupilumab treatment. After stopping and then restarting dupilumab, the patient developed eosinophilic pneumonia. This case highlights the need to monitor blood eosinophil count along with clinical and radiological symptoms in patients receiving dupilumab. |
| format | Article |
| id | doaj-art-4d2f34a5bf454071a25e07c60d218007 |
| institution | Kabale University |
| issn | 2213-0071 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj-art-4d2f34a5bf454071a25e07c60d2180072024-12-13T10:57:48ZengElsevierRespiratory Medicine Case Reports2213-00712024-01-0152102136Erythema nodosum followed by eosinophilic pneumonia as an adverse effect of dupilumab treatment in a patient with severe asthmaAgnieszka Gawlewicz-Mroczka0Marek Przybyszowski1Grażyna Bochenek2Maria Mroczka3Krzysztof Sładek42nd Chair of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, Macieja Jakubowskiego 2, 30-688, Kraków, Poland2nd Chair of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, Macieja Jakubowskiego 2, 30-688, Kraków, Poland; Corresponding author. Macieja Jakubowskiego 2, 30-688, Kraków, Poland.2nd Chair of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, Macieja Jakubowskiego 2, 30-688, Kraków, PolandFaculty of Medicine, Jagiellonian University Medical College, Macieja Jakubowskiego 2, 30-688, Kraków, Poland2nd Chair of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, Macieja Jakubowskiego 2, 30-688, Kraków, PolandDupilumab is a monoclonal antibody that has recently been introduced for the treatment of asthma. It has the potential to significantly alter the progression and severity of T2 -dependent diseases, including severe asthma. However, dupilumab can cause transient hypereosinophilia. In rare cases, hypereosinophilia can reach high levels and manifest with clinical symptoms. We present the case of a female patient who presented with hypereosinophilia of almost 5000 cells/μL accompanied by erythema nodosum during dupilumab treatment. After stopping and then restarting dupilumab, the patient developed eosinophilic pneumonia. This case highlights the need to monitor blood eosinophil count along with clinical and radiological symptoms in patients receiving dupilumab.http://www.sciencedirect.com/science/article/pii/S221300712400159XAsthmaBiologicsEosinophiliaErythema nodosumDupilumab |
| spellingShingle | Agnieszka Gawlewicz-Mroczka Marek Przybyszowski Grażyna Bochenek Maria Mroczka Krzysztof Sładek Erythema nodosum followed by eosinophilic pneumonia as an adverse effect of dupilumab treatment in a patient with severe asthma Respiratory Medicine Case Reports Asthma Biologics Eosinophilia Erythema nodosum Dupilumab |
| title | Erythema nodosum followed by eosinophilic pneumonia as an adverse effect of dupilumab treatment in a patient with severe asthma |
| title_full | Erythema nodosum followed by eosinophilic pneumonia as an adverse effect of dupilumab treatment in a patient with severe asthma |
| title_fullStr | Erythema nodosum followed by eosinophilic pneumonia as an adverse effect of dupilumab treatment in a patient with severe asthma |
| title_full_unstemmed | Erythema nodosum followed by eosinophilic pneumonia as an adverse effect of dupilumab treatment in a patient with severe asthma |
| title_short | Erythema nodosum followed by eosinophilic pneumonia as an adverse effect of dupilumab treatment in a patient with severe asthma |
| title_sort | erythema nodosum followed by eosinophilic pneumonia as an adverse effect of dupilumab treatment in a patient with severe asthma |
| topic | Asthma Biologics Eosinophilia Erythema nodosum Dupilumab |
| url | http://www.sciencedirect.com/science/article/pii/S221300712400159X |
| work_keys_str_mv | AT agnieszkagawlewiczmroczka erythemanodosumfollowedbyeosinophilicpneumoniaasanadverseeffectofdupilumabtreatmentinapatientwithsevereasthma AT marekprzybyszowski erythemanodosumfollowedbyeosinophilicpneumoniaasanadverseeffectofdupilumabtreatmentinapatientwithsevereasthma AT grazynabochenek erythemanodosumfollowedbyeosinophilicpneumoniaasanadverseeffectofdupilumabtreatmentinapatientwithsevereasthma AT mariamroczka erythemanodosumfollowedbyeosinophilicpneumoniaasanadverseeffectofdupilumabtreatmentinapatientwithsevereasthma AT krzysztofsładek erythemanodosumfollowedbyeosinophilicpneumoniaasanadverseeffectofdupilumabtreatmentinapatientwithsevereasthma |