Expert opinion on the current conceptual, clinical and therapeutic aspects of disease related malnutrition and muscle loss: a multidisciplinary perspective
Disease-related malnutrition (DRM) and muscle related conditions (i.e., muscle loss, sarcopenia, and frailty) are overlapping but still underappreciated conditions, which independently and synergistically contribute to an increased risk of adverse health outcomes. Targeted nutritional interventions...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1509689/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849320119607492608 |
|---|---|
| author | Mutlu Doganay Meltem Gulhan Halil Cetin Kaymak Ugur Selek Mehmet Akif Topcuoglu Suayib Yalcin |
| author_facet | Mutlu Doganay Meltem Gulhan Halil Cetin Kaymak Ugur Selek Mehmet Akif Topcuoglu Suayib Yalcin |
| author_sort | Mutlu Doganay |
| collection | DOAJ |
| description | Disease-related malnutrition (DRM) and muscle related conditions (i.e., muscle loss, sarcopenia, and frailty) are overlapping but still underappreciated conditions, which independently and synergistically contribute to an increased risk of adverse health outcomes. Targeted nutritional interventions that can protect and even reverse the muscle loss besides the nutritional status are considered a key clinical priority to improve clinical outcomes and alleviate the joint burden of both malnutrition and muscle loss in malnourished or at-risk patients. Therefore, the proposed expert opinion aimed to address the current conceptual, clinical and therapeutic aspects of DRM and muscle loss from a multidisciplinary perspective in certain risk groups (geriatric patients, cancer patients, patients with neurodegenerative disorders and critically ill patients) and to address the utility of targeted specific nutritional interventions, specifically the high protein nutritional supplements containing β-hydroxy-β-methylbutyrate (HMB) and vitamin D, in terms of potential beneficial effects in preserving and reversing muscle loss beyond meeting nutritional requirements. |
| format | Article |
| id | doaj-art-4d23a9fdfafc4e97978f0e88aecbb204 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-4d23a9fdfafc4e97978f0e88aecbb2042025-08-20T03:50:12ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-07-011210.3389/fnut.2025.15096891509689Expert opinion on the current conceptual, clinical and therapeutic aspects of disease related malnutrition and muscle loss: a multidisciplinary perspectiveMutlu Doganay0Meltem Gulhan Halil1Cetin Kaymak2Ugur Selek3Mehmet Akif Topcuoglu4Suayib Yalcin5Department of General Surgery, Ankara Bilkent City Hospital, Ankara, TürkiyeDepartment of Internal Medicine, Division of Geriatrics, Hacettepe University Faculty of Medicine, Ankara, TürkiyeDepartment of Anesthesiology and Reanimation, University of Health Sciences Ankara Training and Research Hospital, Ankara, TürkiyeDepartment of Radiation Oncology, Koc University School of Medicine, Istanbul, TürkiyeDepartment of Neurology, Hacettepe University Faculty of Medicine, Ankara, TürkiyeDepartment of Medical Oncology, Hacettepe University Faculty of Medicine, Ankara, TürkiyeDisease-related malnutrition (DRM) and muscle related conditions (i.e., muscle loss, sarcopenia, and frailty) are overlapping but still underappreciated conditions, which independently and synergistically contribute to an increased risk of adverse health outcomes. Targeted nutritional interventions that can protect and even reverse the muscle loss besides the nutritional status are considered a key clinical priority to improve clinical outcomes and alleviate the joint burden of both malnutrition and muscle loss in malnourished or at-risk patients. Therefore, the proposed expert opinion aimed to address the current conceptual, clinical and therapeutic aspects of DRM and muscle loss from a multidisciplinary perspective in certain risk groups (geriatric patients, cancer patients, patients with neurodegenerative disorders and critically ill patients) and to address the utility of targeted specific nutritional interventions, specifically the high protein nutritional supplements containing β-hydroxy-β-methylbutyrate (HMB) and vitamin D, in terms of potential beneficial effects in preserving and reversing muscle loss beyond meeting nutritional requirements.https://www.frontiersin.org/articles/10.3389/fnut.2025.1509689/fulldisease-related malnutritionmuscle losssarcopenianutritional interventionhigh proteinHMB |
| spellingShingle | Mutlu Doganay Meltem Gulhan Halil Cetin Kaymak Ugur Selek Mehmet Akif Topcuoglu Suayib Yalcin Expert opinion on the current conceptual, clinical and therapeutic aspects of disease related malnutrition and muscle loss: a multidisciplinary perspective Frontiers in Nutrition disease-related malnutrition muscle loss sarcopenia nutritional intervention high protein HMB |
| title | Expert opinion on the current conceptual, clinical and therapeutic aspects of disease related malnutrition and muscle loss: a multidisciplinary perspective |
| title_full | Expert opinion on the current conceptual, clinical and therapeutic aspects of disease related malnutrition and muscle loss: a multidisciplinary perspective |
| title_fullStr | Expert opinion on the current conceptual, clinical and therapeutic aspects of disease related malnutrition and muscle loss: a multidisciplinary perspective |
| title_full_unstemmed | Expert opinion on the current conceptual, clinical and therapeutic aspects of disease related malnutrition and muscle loss: a multidisciplinary perspective |
| title_short | Expert opinion on the current conceptual, clinical and therapeutic aspects of disease related malnutrition and muscle loss: a multidisciplinary perspective |
| title_sort | expert opinion on the current conceptual clinical and therapeutic aspects of disease related malnutrition and muscle loss a multidisciplinary perspective |
| topic | disease-related malnutrition muscle loss sarcopenia nutritional intervention high protein HMB |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1509689/full |
| work_keys_str_mv | AT mutludoganay expertopiniononthecurrentconceptualclinicalandtherapeuticaspectsofdiseaserelatedmalnutritionandmusclelossamultidisciplinaryperspective AT meltemgulhanhalil expertopiniononthecurrentconceptualclinicalandtherapeuticaspectsofdiseaserelatedmalnutritionandmusclelossamultidisciplinaryperspective AT cetinkaymak expertopiniononthecurrentconceptualclinicalandtherapeuticaspectsofdiseaserelatedmalnutritionandmusclelossamultidisciplinaryperspective AT ugurselek expertopiniononthecurrentconceptualclinicalandtherapeuticaspectsofdiseaserelatedmalnutritionandmusclelossamultidisciplinaryperspective AT mehmetakiftopcuoglu expertopiniononthecurrentconceptualclinicalandtherapeuticaspectsofdiseaserelatedmalnutritionandmusclelossamultidisciplinaryperspective AT suayibyalcin expertopiniononthecurrentconceptualclinicalandtherapeuticaspectsofdiseaserelatedmalnutritionandmusclelossamultidisciplinaryperspective |