Evaluating massage therapy for radiation-induced fibrosis in rats: preliminary findings and palpation results
Radiation-induced fibrosis (RIF) is a common side effect of cancer treatment, but can manifest into a devastating syndrome for which there is no preventive measure or cure. In rats who perform a repetitive work task, who left untreated develop signs and symptoms that resemble repetitive motion disor...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Cancer Biology & Therapy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2024.2436694 |
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| _version_ | 1846125979225817088 |
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| author | Geoffrey M. Bove Holly McMillan Mary F. Barbe |
| author_facet | Geoffrey M. Bove Holly McMillan Mary F. Barbe |
| author_sort | Geoffrey M. Bove |
| collection | DOAJ |
| description | Radiation-induced fibrosis (RIF) is a common side effect of cancer treatment, but can manifest into a devastating syndrome for which there is no preventive measure or cure. In rats who perform a repetitive work task, who left untreated develop signs and symptoms that resemble repetitive motion disorders in humans, we have shown that manual therapy prevents the development of fibrosis and other key biomarkers. The fibrosis of RIF and repetitive motion disorders has similar biomarkers. In rats, we sought to determine if manual therapy would alter key biomarkers of post-irradiation fibrosis following X-ray irradiation given to the rat forelimb. One limb of rats was given a damaging dose of X-ray irradiation. Some limbs were massaged using a protocol previously described and characterized. Serum inflammatory markers, histological assays of tissue fibrosis and nerve pathology, and electrophysiology for neuropathic discharge were assayed after 8 weeks. We also tested if an experienced therapist could identify the irradiated limb using blinded palpation at the 8 week end-point. While preliminary assays showed robust changes compared to control limbs, the other assays did not show similar pathology. Our therapist could detect each irradiated limb. Serum inflammatory markers were reduced by massage to the irradiated limb. We conclude that blinded palpation is sensitive to detect subtle changes in tissue following irradiation. In contrast to the preliminary studies, the dose of irradiation used was insufficient to induce long-lasting deep fibrosis or nerve degeneration. We suspect that a difference in housing, and thus physical activity, was the plausible reason for this difference. |
| format | Article |
| id | doaj-art-4d207072aa74428fa1ac96a49982ab7f |
| institution | Kabale University |
| issn | 1538-4047 1555-8576 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj-art-4d207072aa74428fa1ac96a49982ab7f2024-12-13T06:53:24ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762024-12-0125110.1080/15384047.2024.2436694Evaluating massage therapy for radiation-induced fibrosis in rats: preliminary findings and palpation resultsGeoffrey M. Bove0Holly McMillan1Mary F. Barbe2Owner and Principal Investigator, Bove Consulting, Kennebunkport, ME, USADepartment of Head and Neck Surgery, Senior Speech Pathologist and Clinical Research Fellow, Texas School of Public Health, University of Texas MD Anderson Cancer Center, Houston, TX, USAAging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USARadiation-induced fibrosis (RIF) is a common side effect of cancer treatment, but can manifest into a devastating syndrome for which there is no preventive measure or cure. In rats who perform a repetitive work task, who left untreated develop signs and symptoms that resemble repetitive motion disorders in humans, we have shown that manual therapy prevents the development of fibrosis and other key biomarkers. The fibrosis of RIF and repetitive motion disorders has similar biomarkers. In rats, we sought to determine if manual therapy would alter key biomarkers of post-irradiation fibrosis following X-ray irradiation given to the rat forelimb. One limb of rats was given a damaging dose of X-ray irradiation. Some limbs were massaged using a protocol previously described and characterized. Serum inflammatory markers, histological assays of tissue fibrosis and nerve pathology, and electrophysiology for neuropathic discharge were assayed after 8 weeks. We also tested if an experienced therapist could identify the irradiated limb using blinded palpation at the 8 week end-point. While preliminary assays showed robust changes compared to control limbs, the other assays did not show similar pathology. Our therapist could detect each irradiated limb. Serum inflammatory markers were reduced by massage to the irradiated limb. We conclude that blinded palpation is sensitive to detect subtle changes in tissue following irradiation. In contrast to the preliminary studies, the dose of irradiation used was insufficient to induce long-lasting deep fibrosis or nerve degeneration. We suspect that a difference in housing, and thus physical activity, was the plausible reason for this difference.https://www.tandfonline.com/doi/10.1080/15384047.2024.2436694Musculoskeletal manipulationsradiotherapypost-exposure prophlaxisbrachial plexus neuropathiesphysical examination |
| spellingShingle | Geoffrey M. Bove Holly McMillan Mary F. Barbe Evaluating massage therapy for radiation-induced fibrosis in rats: preliminary findings and palpation results Cancer Biology & Therapy Musculoskeletal manipulations radiotherapy post-exposure prophlaxis brachial plexus neuropathies physical examination |
| title | Evaluating massage therapy for radiation-induced fibrosis in rats: preliminary findings and palpation results |
| title_full | Evaluating massage therapy for radiation-induced fibrosis in rats: preliminary findings and palpation results |
| title_fullStr | Evaluating massage therapy for radiation-induced fibrosis in rats: preliminary findings and palpation results |
| title_full_unstemmed | Evaluating massage therapy for radiation-induced fibrosis in rats: preliminary findings and palpation results |
| title_short | Evaluating massage therapy for radiation-induced fibrosis in rats: preliminary findings and palpation results |
| title_sort | evaluating massage therapy for radiation induced fibrosis in rats preliminary findings and palpation results |
| topic | Musculoskeletal manipulations radiotherapy post-exposure prophlaxis brachial plexus neuropathies physical examination |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2024.2436694 |
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