Effects of autologous platelet-rich plasma in promoting endometrial thickness on patients with thin endometrium following IVF
HIGHLIGHTS • It was observed that autologous PRP substantially increased endometrial thickness in individuals experiencing infertility linked to a thin endometrium. • The elevated clinical pregnancy rate emphasizes the favorable effectiveness of autologous PRP in addressing issues related to a th...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga
2024-11-01
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| Series: | Majalah Obstetri dan Ginekologi |
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| Online Access: | https://e-journal.unair.ac.id/MOG/article/view/52700 |
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| author | Gita Pratama Elizabeth Agustina Atika Mahira Yanfaunnas Mila Maidarti Achmad Kemal Harzif R. Muharam Budi Wiweko |
| author_facet | Gita Pratama Elizabeth Agustina Atika Mahira Yanfaunnas Mila Maidarti Achmad Kemal Harzif R. Muharam Budi Wiweko |
| author_sort | Gita Pratama |
| collection | DOAJ |
| description | HIGHLIGHTS
• It was observed that autologous PRP substantially increased endometrial thickness in individuals experiencing infertility linked to a thin endometrium.
• The elevated clinical pregnancy rate emphasizes the favorable effectiveness of autologous PRP in addressing issues related to a thin endometrium in IVF programs.
ABSTRACT
Objective: The objective of this research was to investigate the impact of autologous platelet-rich plasma (PRP) in enhancing endometrial thickness among individuals experiencing infertility associated with a thin endometrium.
Materials and Methods: Nine individuals with a thin endometrium who participated in an in vitro fertilization (IVF) program were enrolled in the study. This study occurred in Yasmin Clinic, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Patients underwent a hormone replacement protocol involving the preparation of the endometrium with estradiol valerate. Treatment with PRP was initiated when the endometrial thickness was less than 7 mm. Autologous PRP was infused into the uterine cavity between the 10th and 12th days after administering estradiol valerate, and the assessment of endometrial thickness was conducted using ultrasound 48 hours later. A second administration of PRP was provided in cases where the endometrial thickness was below 7 mm. Frozen-thawed embryo transfer (FET) will be performed if the endometrium reaches adequate thickness (minimum 7 mm).
Results: Seven of nine patients had adequate endometrial thickness followed by FET. Endometrial thickness was improved in 8 from 9 patients (88.8%). Five patients were improved at the first autologous PRP infusion (62.5%) and three patients (37.5%) at the second PRP infusion. The implantation rate was 33.3-100%, clinical pregnancy was 100%, and ongoing pregnancy rate was 83.3%.
Conclusion: The use of autologous platelet-rich plasma (PRP) successfully stimulates endometrial development in individuals with a thin endometrium during frozen-thawed embryo transfer. |
| format | Article |
| id | doaj-art-4d0add28d0b24d04a797432dded9ab51 |
| institution | Kabale University |
| issn | 0854-0381 2598-1013 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Majalah Obstetri dan Ginekologi |
| spelling | doaj-art-4d0add28d0b24d04a797432dded9ab512025-01-07T03:23:16ZengUniversitas AirlanggaMajalah Obstetri dan Ginekologi0854-03812598-10132024-11-0132317418010.20473/mog.V32I32024.174-18050860Effects of autologous platelet-rich plasma in promoting endometrial thickness on patients with thin endometrium following IVFGita Pratama0https://orcid.org/0000-0001-5626-1283Elizabeth Agustina1https://orcid.org/0000-0001-6572-6599Atika Mahira Yanfaunnas2https://orcid.org/0009-0000-1451-5310Mila Maidarti3https://orcid.org/0000-0002-4055-4628Achmad Kemal Harzif4https://orcid.org/0000-0002-3552-1610R. Muharam5https://orcid.org/0000-0001-5712-3931Budi Wiweko6https://orcid.org/0000-0002-5898-7034Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, JakartaDepartment of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, JakartaDepartment of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, JakartaYasmin IVF Clinic, dr. Cipto Mangunkusumo General Hospital, JakartaHuman Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, JakartaHuman Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, JakartaDepartment of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, JakartaHIGHLIGHTS • It was observed that autologous PRP substantially increased endometrial thickness in individuals experiencing infertility linked to a thin endometrium. • The elevated clinical pregnancy rate emphasizes the favorable effectiveness of autologous PRP in addressing issues related to a thin endometrium in IVF programs. ABSTRACT Objective: The objective of this research was to investigate the impact of autologous platelet-rich plasma (PRP) in enhancing endometrial thickness among individuals experiencing infertility associated with a thin endometrium. Materials and Methods: Nine individuals with a thin endometrium who participated in an in vitro fertilization (IVF) program were enrolled in the study. This study occurred in Yasmin Clinic, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Patients underwent a hormone replacement protocol involving the preparation of the endometrium with estradiol valerate. Treatment with PRP was initiated when the endometrial thickness was less than 7 mm. Autologous PRP was infused into the uterine cavity between the 10th and 12th days after administering estradiol valerate, and the assessment of endometrial thickness was conducted using ultrasound 48 hours later. A second administration of PRP was provided in cases where the endometrial thickness was below 7 mm. Frozen-thawed embryo transfer (FET) will be performed if the endometrium reaches adequate thickness (minimum 7 mm). Results: Seven of nine patients had adequate endometrial thickness followed by FET. Endometrial thickness was improved in 8 from 9 patients (88.8%). Five patients were improved at the first autologous PRP infusion (62.5%) and three patients (37.5%) at the second PRP infusion. The implantation rate was 33.3-100%, clinical pregnancy was 100%, and ongoing pregnancy rate was 83.3%. Conclusion: The use of autologous platelet-rich plasma (PRP) successfully stimulates endometrial development in individuals with a thin endometrium during frozen-thawed embryo transfer.https://e-journal.unair.ac.id/MOG/article/view/52700platelet-rich plasmaendometrial thicknessthin endometriumin vitro fertilizationreproductive health |
| spellingShingle | Gita Pratama Elizabeth Agustina Atika Mahira Yanfaunnas Mila Maidarti Achmad Kemal Harzif R. Muharam Budi Wiweko Effects of autologous platelet-rich plasma in promoting endometrial thickness on patients with thin endometrium following IVF Majalah Obstetri dan Ginekologi platelet-rich plasma endometrial thickness thin endometrium in vitro fertilization reproductive health |
| title | Effects of autologous platelet-rich plasma in promoting endometrial thickness on patients with thin endometrium following IVF |
| title_full | Effects of autologous platelet-rich plasma in promoting endometrial thickness on patients with thin endometrium following IVF |
| title_fullStr | Effects of autologous platelet-rich plasma in promoting endometrial thickness on patients with thin endometrium following IVF |
| title_full_unstemmed | Effects of autologous platelet-rich plasma in promoting endometrial thickness on patients with thin endometrium following IVF |
| title_short | Effects of autologous platelet-rich plasma in promoting endometrial thickness on patients with thin endometrium following IVF |
| title_sort | effects of autologous platelet rich plasma in promoting endometrial thickness on patients with thin endometrium following ivf |
| topic | platelet-rich plasma endometrial thickness thin endometrium in vitro fertilization reproductive health |
| url | https://e-journal.unair.ac.id/MOG/article/view/52700 |
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