Novel protocol for multiple-dose oral administration of the L-type Ca2+ channel blocker isradipine in mice: A dose-finding pharmacokinetic study

Novel protocol for multiple-dose oral administration of the L-type Ca2+ channel blocker isradipine in mice: A dose-finding pharmacokinetic study

Studies in genetically modified animals and human genetics have recently provided new insight into the role of voltage-gated L-type Ca2+ channels in human disease. Therefore, the inhibition of L-type Ca2+ channels in vivo in wildtype and mutant mice by potent dihydropyridine (DHP) Ca2+ channel block...

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Bibliographic Details
Main Authors:	Tamara Theiner, Nadine J. Ortner, Herbert Oberacher, Gospava Stojanovic, Petronel Tuluc, Jörg Striessnig
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2024-12-01
Series:	Channels
Subjects:	Calcium channel blockers dihydropyridines pharmacokinetics drug administration voltage-gated calcium channels
Online Access:	https://www.tandfonline.com/doi/10.1080/19336950.2024.2335469
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