Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury

Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury

Introduction7,8-Dihydroxyflavone (7,8-DHF) is a promising translational therapy in several brain injury models, including the neonatal hypoxia-ischemia (HI) model in mice. However, the neuroprotective effect of 7,8-DHF was only observed in female, but not male, neonatal mice with HI brain injury. It...

Full description

Saved in:

Bibliographic Details
Main Authors:	Sin Yin Lim, Cameron O. Scarlett, Sefer Yapici, Peter Ferrazzano, Pelin Cengiz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Pharmacology
Subjects:	pharmacokinetics 7,8-dihydroxyflavone hypoxia-ischemia neonate tyrosine kinase B
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1508696/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Rational application of fructose-1,6-diphosphate: From the perspective of pharmacokinetics
by: Li Ting-Ting, et al.
Published: (2015-06-01)

Post-injury treatment with 7,8-dihydroxyflavone attenuates white matter pathology in aged mice following focal traumatic brain injury
by: Georgios Michalettos, et al.
Published: (2025-01-01)

Hypoxia Induced Lnc191 Upregulation Dictates the Progression of Esophageal Squamous Cell Carcinoma by Activating GRP78/ERK Pathway
by: Sisi Wei, et al.
Published: (2025-01-01)

Neuroinflammation mediates the progression of neonate hypoxia-ischemia brain damage to Alzheimer’s disease: a bioinformatics and experimental study
by: Shengjie Zhang, et al.
Published: (2025-01-01)

The Differential Expressions and Associations of Intracellular and Extracellular GRP78/Bip with Disease Activity and Progression in Rheumatoid Arthritis
by: Guoyin Liu, et al.
Published: (2025-01-01)

Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial
by: Liu Y, et al.
Published: (2025-01-01)

Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD traveling to 3,100 m: data from a randomized trial of acetazolamide
by: Marla Christen, et al.
Published: (2025-02-01)

Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway
by: Li Q, et al.
Published: (2025-01-01)

“Seguridad” y “hospitalidad” frente a la “campaña antiargentina”: la construcción de la imagen turística de Buenos Aires para el Mundial 78
by: Mercedes González Bracco
Published: (2024-12-01)

CircWDR78 inhibits the development of colorectal cancer by regulating the miR-653-3p/RGS4 axis
by: Chu Hao, et al.
Published: (2025-02-01)

Do wolframin, P-glycoprotein, and GRP78/BiP cooperate to alter the response of L1210 cells to endoplasmic reticulum stress or drug sensitivity?
by: Simona Kurekova, et al.
Published: (2025-02-01)

Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury
by: Fei Yuan, et al.
Published: (2025-02-01)

7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents
by: Shuke Nie, et al.
Published: (2019-01-01)

Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates
by: Yangyang Gao, et al.
Published: (2025-01-01)

Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine setting of oxygen/glucose deprivation followed by re-oxygenation and is associated with improved neuronal function in ischemic rats
by: Sara Amiranda, et al.
Published: (2025-02-01)

Mechanistic insights into gut microbe derived siderophores and PHD2 interactions with implications for HIF-1α stabilization
by: Jainabbi Irshad Ahmed Patel, et al.
Published: (2025-01-01)

Hypoxia drives the formation of lung micropapillary adenocarcinoma-like structure through hypoxia-inducible factor-1α
by: Daisuke Umeda, et al.
Published: (2024-12-01)

Adaptation of Archaeal Communities to Summer Hypoxia in the Sediment of Bohai Sea
by: Xiaoxiao Guo, et al.
Published: (2025-01-01)

Pharmacokinetic Evaluation of Neutral Sphinghomyelinase2 (nSMase2) Inhibitor Prodrugs in Mice and Dogs
by: Arina Ranjit, et al.
Published: (2024-12-01)

Biological Properties, Bioactive Constituents, and Pharmacokinetics of Some Capsicum spp. and Capsaicinoids
by: Gaber, El-Saber Batiha, et al.
Published: (2023)

Pharmacokinetics of difloxacin after single intravenous, oral and intramuscular administration in pigeons
by: Yang-Guang Jin, et al.
Published: (2025-02-01)

Impact of Hypoxia on the Community Structure of Benthic Macroinvertebrates of Lagos Lagoon, Nigeria
by: Nkwoji Joseph Ahamefula
Published: (2016-05-01)

Impact of Hypoxia on the Community Structure of Benthic Macroinvertebrates of Lagos Lagoon, Nigeria
by: Nkwoji Joseph Ahamefula
Published: (2016-05-01)

Development and Application of Physiologically-Based Pharmacokinetic Model to Predict Systemic and Organ Exposure of Colorectal Cancer Drugs
by: Sara Peribañez-Dominguez, et al.
Published: (2025-01-01)

A comprehensive review on the plant sources, pharmacological activities and pharmacokinetic characteristics of Syringaresinol
by: Lei Zhang, et al.
Published: (2025-02-01)

Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations
by: Pratibha Pandey, et al.
Published: (2025-01-01)

A potential innovative surrogate marker for hypoxic injury: Shehata marker of angiogenesis
by: Shehata A. Mohamed
Published: (2025-01-01)

hUC-MSC extracellular vesicles protect against hypoxic-ischemic brain injury by promoting NLRP3 ubiquitination
by: Shanshan Xiao, et al.
Published: (2024-12-01)

Analysis of HIV therapy in the liver using optimal control and pharmacokinetics
by: Hasifa Nampala, et al.
Published: (2025-01-01)

Association of serum and local GRP78 and CHOP expressions with disease progression in patients with non-traumatic osteonecrosis of femoral head
by: Peng Zhang, et al.
Published: (2025-01-01)

The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin—A Randomized, Controlled, Crossover Study
by: Liva K. Stuhr, et al.
Published: (2025-01-01)

Population Pharmacokinetic of Epidural Sufentanil in Labouring Women: A Multicentric, Prospective, Observational Study
by: Nie Y, et al.
Published: (2025-02-01)

Pharmacokinetics of Maternal Drug Administration: Insights into Placental Transfer and Fetal Exposure
by: Abdullah Duhaim, et al.
Published: (2024-12-01)

Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs
by: Wang Wusan, et al.
Published: (2016-06-01)

Clinical Pharmacokinetics of Atogepant in Healthy Japanese and White Adults
by: Ramesh R. Boinpally, et al.
Published: (2025-01-01)

Expression and Regulation of Hypoxia-Inducible Factor Signalling in Acute Lung Inflammation
by: Nikolaos S. Lotsios, et al.
Published: (2024-12-01)

Study of Salidroside on Expression of Synaptophysin and Tau in Rats after Local Cerebral Ischemia-reperfusion Injury
by: Yanqing SU, et al.
Published: (2017-12-01)

A review of the Bovis Calculus’s intervention mechanism and clinical application in ischemic stroke
by: Ke Xu, et al.
Published: (2025-01-01)

Characteristics of transcriptome and chromatin accessibility in the peripheral blood after acute hypoxia exposure
by: Kuo Zeng, et al.
Published: (2025-01-01)

Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats
by: Zhou Zhaoxiang, et al.
Published: (2016-12-01)