Vitamin D Supplementation and Colorectal Cancer Patients Outcomes
Colorectal cancer is the third most encountered malignancy worldwide in 2018. Some earlier studies indicate a significant influence of vitamin D supplementation on the 5-year survival rate and the rate of metastasis progression in colorectal cancer patients. Studies investigating the effects of vita...
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| Format: | Article |
| Language: | English |
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Universitas Padjajaran
2024-12-01
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| Series: | Majalah Kedokteran Bandung |
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| Online Access: | https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3823 |
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| author | Noeray Pratiwi Mulyadi Reno Rudiman Andriana Purnama |
| author_facet | Noeray Pratiwi Mulyadi Reno Rudiman Andriana Purnama |
| author_sort | Noeray Pratiwi Mulyadi |
| collection | DOAJ |
| description | Colorectal cancer is the third most encountered malignancy worldwide in 2018. Some earlier studies indicate a significant influence of vitamin D supplementation on the 5-year survival rate and the rate of metastasis progression in colorectal cancer patients. Studies investigating the effects of vitamin D supplementation on the outcomes of colorectal cancer patients are limited in Indonesia. Therefore, a double-blinded Randomized Controlled Trial (RCT) of the effect of vitamin D supplementation on the outcome of colorectal cancer patients was conducted from April 2022 to March 2023 at the digestive surgery outpatient clinic of Dr. Hasan Sadikin General Hospital Bandung, Indonesia. In this study, 36 patients received vitamin D and 34 patients received a placebo. Data analysis performed using the multivariate analysis with multiple regression revealed no significant relationship between vitamin D supplementation and colorectal cancer patient outcomes. Furthermore, ANOVA analysis indicated no relationship between the analyzed independent and dependent variables in this study. No relationship was found between vitamin D supplementation and the outcomes of metastasis, mortality, and Karnofsky scores in colorectal cancer patients. Further research with a larger population is still needed to determine the benefits of vitamin D supplementation on the outcomes of colorectal cancer patients. |
| format | Article |
| id | doaj-art-4ce9fd3304154daf9c241a0fbd4bfc01 |
| institution | Kabale University |
| issn | 0126-074X 2338-6223 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Universitas Padjajaran |
| record_format | Article |
| series | Majalah Kedokteran Bandung |
| spelling | doaj-art-4ce9fd3304154daf9c241a0fbd4bfc012025-08-20T03:58:18ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232024-12-0156429230210.15395/mkb.v56.38231791Vitamin D Supplementation and Colorectal Cancer Patients OutcomesNoeray Pratiwi Mulyadi0Reno Rudiman1Andriana Purnama2Department of Surgery, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, BandungDivision of Digestive Surgery, Department of Surgery, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, BandungDivision of Digestive Surgery, Department of Surgery, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, BandungColorectal cancer is the third most encountered malignancy worldwide in 2018. Some earlier studies indicate a significant influence of vitamin D supplementation on the 5-year survival rate and the rate of metastasis progression in colorectal cancer patients. Studies investigating the effects of vitamin D supplementation on the outcomes of colorectal cancer patients are limited in Indonesia. Therefore, a double-blinded Randomized Controlled Trial (RCT) of the effect of vitamin D supplementation on the outcome of colorectal cancer patients was conducted from April 2022 to March 2023 at the digestive surgery outpatient clinic of Dr. Hasan Sadikin General Hospital Bandung, Indonesia. In this study, 36 patients received vitamin D and 34 patients received a placebo. Data analysis performed using the multivariate analysis with multiple regression revealed no significant relationship between vitamin D supplementation and colorectal cancer patient outcomes. Furthermore, ANOVA analysis indicated no relationship between the analyzed independent and dependent variables in this study. No relationship was found between vitamin D supplementation and the outcomes of metastasis, mortality, and Karnofsky scores in colorectal cancer patients. Further research with a larger population is still needed to determine the benefits of vitamin D supplementation on the outcomes of colorectal cancer patients.https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3823colorectal neoplasms, neoplasm metastasis, mortality, vitamin d, supplementation |
| spellingShingle | Noeray Pratiwi Mulyadi Reno Rudiman Andriana Purnama Vitamin D Supplementation and Colorectal Cancer Patients Outcomes Majalah Kedokteran Bandung colorectal neoplasms, neoplasm metastasis, mortality, vitamin d, supplementation |
| title | Vitamin D Supplementation and Colorectal Cancer Patients Outcomes |
| title_full | Vitamin D Supplementation and Colorectal Cancer Patients Outcomes |
| title_fullStr | Vitamin D Supplementation and Colorectal Cancer Patients Outcomes |
| title_full_unstemmed | Vitamin D Supplementation and Colorectal Cancer Patients Outcomes |
| title_short | Vitamin D Supplementation and Colorectal Cancer Patients Outcomes |
| title_sort | vitamin d supplementation and colorectal cancer patients outcomes |
| topic | colorectal neoplasms, neoplasm metastasis, mortality, vitamin d, supplementation |
| url | https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3823 |
| work_keys_str_mv | AT noeraypratiwimulyadi vitamindsupplementationandcolorectalcancerpatientsoutcomes AT renorudiman vitamindsupplementationandcolorectalcancerpatientsoutcomes AT andrianapurnama vitamindsupplementationandcolorectalcancerpatientsoutcomes |