The Efficacy of Chimeric Antigen Therapy in Viral Infectious Diseases: A Systematic Review of Randomized Controlled Trials
Infectious diseases are among the most important global health problems, and their burden on society is wide. It is shown that chimeric antigen receptor (CAR) T-cell therapy can fight viral infectious diseases in many aspects. This systematic review investigated the efficacy of CAR T-cell therapy ag...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-12-01
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| Series: | Turkish Journal of Immunology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tji&un=TJI-92063 |
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| _version_ | 1841525616208248832 |
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| author | Hossein Hatami Elnaz Ataei Mohammadjavad Nasiri Hamed Ghorani |
| author_facet | Hossein Hatami Elnaz Ataei Mohammadjavad Nasiri Hamed Ghorani |
| author_sort | Hossein Hatami |
| collection | DOAJ |
| description | Infectious diseases are among the most important global health problems, and their burden on society is wide. It is shown that chimeric antigen receptor (CAR) T-cell therapy can fight viral infectious diseases in many aspects. This systematic review investigated the efficacy of CAR T-cell therapy against viral infections. A comprehensive literature search was conducted in Medline, Scopus, Cochrane Central Library, and Embase up to May 2024. Keywords such as CAR T-cell therapy, viral, virus, and infection were used to identify relevant studies. In the identification stage, a comprehensive search across databases, including Medline, Scopus, Cochrane Central Library, and Embase, identified 12183 papers. Finally, 7 articles with total of 134 individuals were examined. Three studies investigated the efficacy of CAR T-cell therapy against human immunodeficiency virus (HIV), hepatitis B virus (HBV), and cytomegalovirus (CMV). The primary objectives of these trials were to assess the safety and feasibility of adoptive transfer of CAR T-cells in patients with viral infections. The aforementioned results demonstrate the efficacy of CAR T-cell therapy in targeting viral antigens and inhibiting viral replication, providing possible treatment options for long-term infectious illnesses like HIV, HBV, and CMV. These findings show the efficacy of CAR T-cell therapy in infectious diseases, but the data are limited. To maximize the efficacy of CAR T-cell therapy and clarify its long-term effectiveness in the treatment of infectious diseases, more investigation and clinical studies are required. |
| format | Article |
| id | doaj-art-4cce87f53a0d4dfab4e1d7032525d360 |
| institution | Kabale University |
| issn | 1301-109X 2147-8325 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Immunology |
| spelling | doaj-art-4cce87f53a0d4dfab4e1d7032525d3602025-01-17T08:29:34ZengGalenos Publishing HouseTurkish Journal of Immunology1301-109X2147-83252024-12-01123849110.4274/tji.galenos.2024.92063TJI-92063The Efficacy of Chimeric Antigen Therapy in Viral Infectious Diseases: A Systematic Review of Randomized Controlled TrialsHossein Hatami0Elnaz Ataei1Mohammadjavad Nasiri2Hamed Ghorani3Shahid Beheshti University of Medical Sciences, School of Public Health and Environmental and Occupational Hazards Control Research Center,Department of Public Health, Tehran, IranShahid Beheshti University of Medical Sciences, Shahid Modarres Educational Hospital, Clinical Research Development Center, Tehran, IranShahid Beheshti University of Medical Sciences School of Medicine, Department of Microbiology, Tehran, IranTehran University of Medical Science, Advanced Diagnostic and Interventional Radiology Research Center, Tehran, IranInfectious diseases are among the most important global health problems, and their burden on society is wide. It is shown that chimeric antigen receptor (CAR) T-cell therapy can fight viral infectious diseases in many aspects. This systematic review investigated the efficacy of CAR T-cell therapy against viral infections. A comprehensive literature search was conducted in Medline, Scopus, Cochrane Central Library, and Embase up to May 2024. Keywords such as CAR T-cell therapy, viral, virus, and infection were used to identify relevant studies. In the identification stage, a comprehensive search across databases, including Medline, Scopus, Cochrane Central Library, and Embase, identified 12183 papers. Finally, 7 articles with total of 134 individuals were examined. Three studies investigated the efficacy of CAR T-cell therapy against human immunodeficiency virus (HIV), hepatitis B virus (HBV), and cytomegalovirus (CMV). The primary objectives of these trials were to assess the safety and feasibility of adoptive transfer of CAR T-cells in patients with viral infections. The aforementioned results demonstrate the efficacy of CAR T-cell therapy in targeting viral antigens and inhibiting viral replication, providing possible treatment options for long-term infectious illnesses like HIV, HBV, and CMV. These findings show the efficacy of CAR T-cell therapy in infectious diseases, but the data are limited. To maximize the efficacy of CAR T-cell therapy and clarify its long-term effectiveness in the treatment of infectious diseases, more investigation and clinical studies are required.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tji&un=TJI-92063chimeric antigen therapyviral infectious diseaseshepatitis |
| spellingShingle | Hossein Hatami Elnaz Ataei Mohammadjavad Nasiri Hamed Ghorani The Efficacy of Chimeric Antigen Therapy in Viral Infectious Diseases: A Systematic Review of Randomized Controlled Trials Turkish Journal of Immunology chimeric antigen therapy viral infectious diseases hepatitis |
| title | The Efficacy of Chimeric Antigen Therapy in Viral Infectious Diseases: A Systematic Review of Randomized Controlled Trials |
| title_full | The Efficacy of Chimeric Antigen Therapy in Viral Infectious Diseases: A Systematic Review of Randomized Controlled Trials |
| title_fullStr | The Efficacy of Chimeric Antigen Therapy in Viral Infectious Diseases: A Systematic Review of Randomized Controlled Trials |
| title_full_unstemmed | The Efficacy of Chimeric Antigen Therapy in Viral Infectious Diseases: A Systematic Review of Randomized Controlled Trials |
| title_short | The Efficacy of Chimeric Antigen Therapy in Viral Infectious Diseases: A Systematic Review of Randomized Controlled Trials |
| title_sort | efficacy of chimeric antigen therapy in viral infectious diseases a systematic review of randomized controlled trials |
| topic | chimeric antigen therapy viral infectious diseases hepatitis |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tji&un=TJI-92063 |
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