GENETIC PATHWAYS LEADING TO THERAPY-RELATED MYELOID NEOPLASMS
Therapy-related myeloid neoplasm (t-MN) is a distinctive clinical syndrome occurring after exposure to chemotherapy or radiotherapy. t-MN arises in most cases from a multipotential hematopoietic stem cell or, less commonly, in a lineage committed progenitor cell. The prognosis for patients with t-...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2011-05-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/287 |
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| author | Angela Stoddart Megan E. McNerney Elizabeth Bartom Rachel Bergerson David J. Young Zhijian Qian Jianghong Wang Anthony A. Fernald Elizabeth M. Davis Richard A. Larson Kevin P. White Michelle M. Le Beau |
| author_facet | Angela Stoddart Megan E. McNerney Elizabeth Bartom Rachel Bergerson David J. Young Zhijian Qian Jianghong Wang Anthony A. Fernald Elizabeth M. Davis Richard A. Larson Kevin P. White Michelle M. Le Beau |
| author_sort | Angela Stoddart |
| collection | DOAJ |
| description | Therapy-related myeloid neoplasm (t-MN) is a distinctive clinical syndrome occurring after exposure to chemotherapy or radiotherapy. t-MN arises in most cases from a multipotential hematopoietic stem cell or, less commonly, in a lineage committed progenitor cell. The prognosis for patients with t-MN is poor, as current forms of therapy are largely ineffective. Cytogenetic analysis, molecular analysis and gene expression profiling analysis of t-MN has revealed that there are distinct subtypes of the disease; however, our understanding of the genetic basis of t-MN is incomplete. Elucidating the genetic pathways and molecular networks that are perturbed in t-MNs, may facilitate the identification of therapeutic targets that can be exploited for the development of urgently-needed targeted therapies. |
| format | Article |
| id | doaj-art-4cca1ac43731402e9e66cd18a6746d3d |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2011-05-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-4cca1ac43731402e9e66cd18a6746d3d2025-01-02T01:18:55ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062011-05-0131e2011019e201101910.4084/mjhid.2011.019179GENETIC PATHWAYS LEADING TO THERAPY-RELATED MYELOID NEOPLASMSAngela StoddartMegan E. McNerneyElizabeth BartomRachel BergersonDavid J. YoungZhijian QianJianghong WangAnthony A. FernaldElizabeth M. DavisRichard A. LarsonKevin P. WhiteMichelle M. Le BeauTherapy-related myeloid neoplasm (t-MN) is a distinctive clinical syndrome occurring after exposure to chemotherapy or radiotherapy. t-MN arises in most cases from a multipotential hematopoietic stem cell or, less commonly, in a lineage committed progenitor cell. The prognosis for patients with t-MN is poor, as current forms of therapy are largely ineffective. Cytogenetic analysis, molecular analysis and gene expression profiling analysis of t-MN has revealed that there are distinct subtypes of the disease; however, our understanding of the genetic basis of t-MN is incomplete. Elucidating the genetic pathways and molecular networks that are perturbed in t-MNs, may facilitate the identification of therapeutic targets that can be exploited for the development of urgently-needed targeted therapies.http://www.mjhid.org/index.php/mjhid/article/view/287therapy-related myeloid neoplasms, genetic pathways, cytogenetic abnormalities, del(5q) |
| spellingShingle | Angela Stoddart Megan E. McNerney Elizabeth Bartom Rachel Bergerson David J. Young Zhijian Qian Jianghong Wang Anthony A. Fernald Elizabeth M. Davis Richard A. Larson Kevin P. White Michelle M. Le Beau GENETIC PATHWAYS LEADING TO THERAPY-RELATED MYELOID NEOPLASMS Mediterranean Journal of Hematology and Infectious Diseases therapy-related myeloid neoplasms, genetic pathways, cytogenetic abnormalities, del(5q) |
| title | GENETIC PATHWAYS LEADING TO THERAPY-RELATED MYELOID NEOPLASMS |
| title_full | GENETIC PATHWAYS LEADING TO THERAPY-RELATED MYELOID NEOPLASMS |
| title_fullStr | GENETIC PATHWAYS LEADING TO THERAPY-RELATED MYELOID NEOPLASMS |
| title_full_unstemmed | GENETIC PATHWAYS LEADING TO THERAPY-RELATED MYELOID NEOPLASMS |
| title_short | GENETIC PATHWAYS LEADING TO THERAPY-RELATED MYELOID NEOPLASMS |
| title_sort | genetic pathways leading to therapy related myeloid neoplasms |
| topic | therapy-related myeloid neoplasms, genetic pathways, cytogenetic abnormalities, del(5q) |
| url | http://www.mjhid.org/index.php/mjhid/article/view/287 |
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