HYPERTENSION AND DRUG-INDUCED GINGIVAL OVERGROWTH: MECHANISMS, IMPLICATIONS, AND MANAGEMENT STRATEGIES
Hypertension (HTA) is commonly treated with medications that can cause drug-induced gingival overgrowth (DIGO). This study investigates the mechanisms behind DIGO in hypertensive patients, focusing on the effects of calcium channel blockers, immunosuppressants, and anticonvulsants. We explore the ce...
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| Format: | Article |
| Language: | English |
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Romanian Dental Association for Education
2024-06-01
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| Series: | Romanian Journal of Medical and Dental Education |
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| Online Access: | https://journal.adre.ro/hypertension-and-drug-induced-gingival-overgrowth-mechanisms-implications-and-management-strategies/ |
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| author | Bogdan Amărioarei Diana Tatarciuc Gabriel Rotundu Ruxandra Stan Oana Butnaru Alexandra Mârțu Liliana Păsărin Ionut Luchian |
| author_facet | Bogdan Amărioarei Diana Tatarciuc Gabriel Rotundu Ruxandra Stan Oana Butnaru Alexandra Mârțu Liliana Păsărin Ionut Luchian |
| author_sort | Bogdan Amărioarei |
| collection | DOAJ |
| description | Hypertension (HTA) is commonly treated with medications that can cause drug-induced gingival overgrowth (DIGO). This study investigates the mechanisms behind DIGO in hypertensive patients, focusing on the effects of calcium channel blockers, immunosuppressants, and anticonvulsants. We explore the cellular and molecular pathways involved, such as collagen synthesis, inflammation, and the role of integrins. Clinical implications include challenges in oral hygiene, periodontal health, and patient quality of life. Management strategies discussed include drug substitution, enhanced oral hygiene, and surgical options. Understanding the link between HTA treatment and gingival overgrowth can help healthcare providers better diagnose and manage this condition, improving patient outcomes and periodontal health. |
| format | Article |
| id | doaj-art-4c80924c1c94482cb65f724d492fdc71 |
| institution | Kabale University |
| issn | 2393-1531 2393-1108 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Romanian Dental Association for Education |
| record_format | Article |
| series | Romanian Journal of Medical and Dental Education |
| spelling | doaj-art-4c80924c1c94482cb65f724d492fdc712025-01-08T08:03:47ZengRomanian Dental Association for EducationRomanian Journal of Medical and Dental Education2393-15312393-11082024-06-011335664HYPERTENSION AND DRUG-INDUCED GINGIVAL OVERGROWTH: MECHANISMS, IMPLICATIONS, AND MANAGEMENT STRATEGIESBogdan Amărioarei0Diana Tatarciuc1Gabriel Rotundu2Ruxandra Stan3Oana Butnaru4Alexandra Mârțu5Liliana Păsărin6Ionut Luchian7Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaDepartment of Internal Medicine, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaDepartment of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaFaculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaDepartment of Biophysics, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaDepartment of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaDepartment of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaDepartment of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaHypertension (HTA) is commonly treated with medications that can cause drug-induced gingival overgrowth (DIGO). This study investigates the mechanisms behind DIGO in hypertensive patients, focusing on the effects of calcium channel blockers, immunosuppressants, and anticonvulsants. We explore the cellular and molecular pathways involved, such as collagen synthesis, inflammation, and the role of integrins. Clinical implications include challenges in oral hygiene, periodontal health, and patient quality of life. Management strategies discussed include drug substitution, enhanced oral hygiene, and surgical options. Understanding the link between HTA treatment and gingival overgrowth can help healthcare providers better diagnose and manage this condition, improving patient outcomes and periodontal health.https://journal.adre.ro/hypertension-and-drug-induced-gingival-overgrowth-mechanisms-implications-and-management-strategies/drug-induced gingival overgrowthhypertensioncalcium channel blockerscollagen synthesis |
| spellingShingle | Bogdan Amărioarei Diana Tatarciuc Gabriel Rotundu Ruxandra Stan Oana Butnaru Alexandra Mârțu Liliana Păsărin Ionut Luchian HYPERTENSION AND DRUG-INDUCED GINGIVAL OVERGROWTH: MECHANISMS, IMPLICATIONS, AND MANAGEMENT STRATEGIES Romanian Journal of Medical and Dental Education drug-induced gingival overgrowth hypertension calcium channel blockers collagen synthesis |
| title | HYPERTENSION AND DRUG-INDUCED GINGIVAL OVERGROWTH: MECHANISMS, IMPLICATIONS, AND MANAGEMENT STRATEGIES |
| title_full | HYPERTENSION AND DRUG-INDUCED GINGIVAL OVERGROWTH: MECHANISMS, IMPLICATIONS, AND MANAGEMENT STRATEGIES |
| title_fullStr | HYPERTENSION AND DRUG-INDUCED GINGIVAL OVERGROWTH: MECHANISMS, IMPLICATIONS, AND MANAGEMENT STRATEGIES |
| title_full_unstemmed | HYPERTENSION AND DRUG-INDUCED GINGIVAL OVERGROWTH: MECHANISMS, IMPLICATIONS, AND MANAGEMENT STRATEGIES |
| title_short | HYPERTENSION AND DRUG-INDUCED GINGIVAL OVERGROWTH: MECHANISMS, IMPLICATIONS, AND MANAGEMENT STRATEGIES |
| title_sort | hypertension and drug induced gingival overgrowth mechanisms implications and management strategies |
| topic | drug-induced gingival overgrowth hypertension calcium channel blockers collagen synthesis |
| url | https://journal.adre.ro/hypertension-and-drug-induced-gingival-overgrowth-mechanisms-implications-and-management-strategies/ |
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