Neoadjuvant Intra-arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma
Adenoid cystic carcinoma (ACC) is the most common lacrimal gland malignancy. Despite poor prognosis, the advent of neoadjuvant intra-arterial cytoreductive chemotherapy (IACC) can improve survival. We report the first case of lacrimal gland ACC from the Indian subcontinent managed with IACC. A 45-ye...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | TNOA Journal of Ophthalmic Science and Research |
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| Online Access: | https://journals.lww.com/10.4103/tjosr.tjosr_96_24 |
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| author | Vathsalya Vijay Avriel I. Gudkar Kirthi Koka Bipasha Mukherjee |
| author_facet | Vathsalya Vijay Avriel I. Gudkar Kirthi Koka Bipasha Mukherjee |
| author_sort | Vathsalya Vijay |
| collection | DOAJ |
| description | Adenoid cystic carcinoma (ACC) is the most common lacrimal gland malignancy. Despite poor prognosis, the advent of neoadjuvant intra-arterial cytoreductive chemotherapy (IACC) can improve survival. We report the first case of lacrimal gland ACC from the Indian subcontinent managed with IACC. A 45-year-old gentleman presented with painful proptosis with restricted ocular movements in right eye for 6 months. Imaging showed an ill-defined heterogeneous mass involving the right lacrimal gland with calcification and adjacent bony erosion. Incision biopsy confirmed the diagnosis of lacrimal gland ACC. He received 2 cycles of neoadjuvant intra-arterial cisplatin before tumour excision followed by adjuvant chemoradiation. He had no recurrence at 6 years of follow-up. IACC helps to reduce tumour size, thereby enabling complete tumour excision and globe salvage. IACC is a treatment option worth considering for patients presenting with a large lacrimal gland ACC. |
| format | Article |
| id | doaj-art-4c7db8de0b1a4505af112c7fc1b00a9a |
| institution | Kabale University |
| issn | 2589-4528 2589-4536 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | TNOA Journal of Ophthalmic Science and Research |
| spelling | doaj-art-4c7db8de0b1a4505af112c7fc1b00a9a2025-01-16T07:08:01ZengWolters Kluwer Medknow PublicationsTNOA Journal of Ophthalmic Science and Research2589-45282589-45362024-12-0162447147310.4103/tjosr.tjosr_96_24Neoadjuvant Intra-arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic CarcinomaVathsalya VijayAvriel I. GudkarKirthi KokaBipasha MukherjeeAdenoid cystic carcinoma (ACC) is the most common lacrimal gland malignancy. Despite poor prognosis, the advent of neoadjuvant intra-arterial cytoreductive chemotherapy (IACC) can improve survival. We report the first case of lacrimal gland ACC from the Indian subcontinent managed with IACC. A 45-year-old gentleman presented with painful proptosis with restricted ocular movements in right eye for 6 months. Imaging showed an ill-defined heterogeneous mass involving the right lacrimal gland with calcification and adjacent bony erosion. Incision biopsy confirmed the diagnosis of lacrimal gland ACC. He received 2 cycles of neoadjuvant intra-arterial cisplatin before tumour excision followed by adjuvant chemoradiation. He had no recurrence at 6 years of follow-up. IACC helps to reduce tumour size, thereby enabling complete tumour excision and globe salvage. IACC is a treatment option worth considering for patients presenting with a large lacrimal gland ACC.https://journals.lww.com/10.4103/tjosr.tjosr_96_24adenoid cystic carcinomaintra-arterial chemotherapylacrimal gland |
| spellingShingle | Vathsalya Vijay Avriel I. Gudkar Kirthi Koka Bipasha Mukherjee Neoadjuvant Intra-arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma TNOA Journal of Ophthalmic Science and Research adenoid cystic carcinoma intra-arterial chemotherapy lacrimal gland |
| title | Neoadjuvant Intra-arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma |
| title_full | Neoadjuvant Intra-arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma |
| title_fullStr | Neoadjuvant Intra-arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma |
| title_full_unstemmed | Neoadjuvant Intra-arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma |
| title_short | Neoadjuvant Intra-arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma |
| title_sort | neoadjuvant intra arterial cytoreductive chemotherapy for lacrimal gland adenoid cystic carcinoma |
| topic | adenoid cystic carcinoma intra-arterial chemotherapy lacrimal gland |
| url | https://journals.lww.com/10.4103/tjosr.tjosr_96_24 |
| work_keys_str_mv | AT vathsalyavijay neoadjuvantintraarterialcytoreductivechemotherapyforlacrimalglandadenoidcysticcarcinoma AT avrieligudkar neoadjuvantintraarterialcytoreductivechemotherapyforlacrimalglandadenoidcysticcarcinoma AT kirthikoka neoadjuvantintraarterialcytoreductivechemotherapyforlacrimalglandadenoidcysticcarcinoma AT bipashamukherjee neoadjuvantintraarterialcytoreductivechemotherapyforlacrimalglandadenoidcysticcarcinoma |