A clinical evaluation of variation in paediatric intracranial pressure waveforms
Introduction: Intracranial pressure (ICP) monitoring is commonly used in investigating the aetiology of chronic paediatric neurological conditions. A series of high-amplitude spikes has been observed in overnight ICP recordings of some children, many of whom have hydrocephalus or craniosynostosis. R...
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Elsevier
2024-01-01
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| Series: | Brain and Spine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772529424001152 |
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| author | Amarah Saeed Richard Boulton Roddy O'Kane Martin Shaw Laura Moss |
| author_facet | Amarah Saeed Richard Boulton Roddy O'Kane Martin Shaw Laura Moss |
| author_sort | Amarah Saeed |
| collection | DOAJ |
| description | Introduction: Intracranial pressure (ICP) monitoring is commonly used in investigating the aetiology of chronic paediatric neurological conditions. A series of high-amplitude spikes has been observed in overnight ICP recordings of some children, many of whom have hydrocephalus or craniosynostosis. Research question: This clinical evaluation aimed to define the spike pattern, describe the patient group in which it is most likely to occur, and conduct high-resolution waveform analysis. Material and methods: ICP waveforms from 40 patients aged 0–5 years (inclusive), recorded between 2017 and 2021 at the Royal Hospital for Children Glasgow, were retrospectively analysed. The pattern was defined through visual inspection of regions of interest by two reviewers. Patients were stratified using demographic and clinical data. R software was used to perform regression and high-resolution waveform analyses. Results: The spike pattern was defined as the presence of 2 consecutive spikes with an amplitude of at least 8 mmHg, with a gap of at least 30 min between spikes. In the adjusted Poisson regression, age was significantly associated with the number of spikes (IRR 0.8, 95% CI 0.70 to 0.92, p-value 0.001). Discussion and conclusion: Younger age was significantly associated with an increased number of spikes in this cohort. Investigation of clinical consequences of the spikes is warranted. |
| format | Article |
| id | doaj-art-4c7a0ab6ace04880bdd3a0f3a056e87a |
| institution | Kabale University |
| issn | 2772-5294 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain and Spine |
| spelling | doaj-art-4c7a0ab6ace04880bdd3a0f3a056e87a2024-12-15T06:18:35ZengElsevierBrain and Spine2772-52942024-01-014102859A clinical evaluation of variation in paediatric intracranial pressure waveformsAmarah Saeed0Richard Boulton1Roddy O'Kane2Martin Shaw3Laura Moss4School of Medicine, University of Glasgow, Scotland, United Kingdom; Corresponding author. School of Medicine, University of Glasgow, G12. 8QQ, United Kingdom.Department of Clinical Physics and Bioengineering, NHS Greater Glasgow and Clyde, Scotland, United KingdomRoyal Hospital for Children & Institute of Neurological Sciences, 1345 Govan Road, Glasgow, Scotland, United KingdomDepartment of Clinical Physics and Bioengineering, NHS Greater Glasgow and Clyde, Scotland, United KingdomDepartment of Clinical Physics and Bioengineering, NHS Greater Glasgow and Clyde, Scotland, United KingdomIntroduction: Intracranial pressure (ICP) monitoring is commonly used in investigating the aetiology of chronic paediatric neurological conditions. A series of high-amplitude spikes has been observed in overnight ICP recordings of some children, many of whom have hydrocephalus or craniosynostosis. Research question: This clinical evaluation aimed to define the spike pattern, describe the patient group in which it is most likely to occur, and conduct high-resolution waveform analysis. Material and methods: ICP waveforms from 40 patients aged 0–5 years (inclusive), recorded between 2017 and 2021 at the Royal Hospital for Children Glasgow, were retrospectively analysed. The pattern was defined through visual inspection of regions of interest by two reviewers. Patients were stratified using demographic and clinical data. R software was used to perform regression and high-resolution waveform analyses. Results: The spike pattern was defined as the presence of 2 consecutive spikes with an amplitude of at least 8 mmHg, with a gap of at least 30 min between spikes. In the adjusted Poisson regression, age was significantly associated with the number of spikes (IRR 0.8, 95% CI 0.70 to 0.92, p-value 0.001). Discussion and conclusion: Younger age was significantly associated with an increased number of spikes in this cohort. Investigation of clinical consequences of the spikes is warranted.http://www.sciencedirect.com/science/article/pii/S2772529424001152Intracranial pressureIntracranial pressure monitoringPaediatric intracranial pressure waveformsPaediatric hydrocephalusPaediatric craniosynostosisPlateau waves |
| spellingShingle | Amarah Saeed Richard Boulton Roddy O'Kane Martin Shaw Laura Moss A clinical evaluation of variation in paediatric intracranial pressure waveforms Brain and Spine Intracranial pressure Intracranial pressure monitoring Paediatric intracranial pressure waveforms Paediatric hydrocephalus Paediatric craniosynostosis Plateau waves |
| title | A clinical evaluation of variation in paediatric intracranial pressure waveforms |
| title_full | A clinical evaluation of variation in paediatric intracranial pressure waveforms |
| title_fullStr | A clinical evaluation of variation in paediatric intracranial pressure waveforms |
| title_full_unstemmed | A clinical evaluation of variation in paediatric intracranial pressure waveforms |
| title_short | A clinical evaluation of variation in paediatric intracranial pressure waveforms |
| title_sort | clinical evaluation of variation in paediatric intracranial pressure waveforms |
| topic | Intracranial pressure Intracranial pressure monitoring Paediatric intracranial pressure waveforms Paediatric hydrocephalus Paediatric craniosynostosis Plateau waves |
| url | http://www.sciencedirect.com/science/article/pii/S2772529424001152 |
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