Transcriptome reveals the landscape of alveolar macrophages exposed to combined hypoxia with cigarette smoke extract

Transcriptome reveals the landscape of alveolar macrophages exposed to combined hypoxia with cigarette smoke extract

Abstract Background Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous chronic inflammatory disease that is one of the leading causes of age-standardised deaths globally. While studies have investigated altitude's effects on COPD, none have explored alveolar macrophage...

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Bibliographic Details
Main Authors: Qing Liu, Yushi Zhang, Ruirui Duan, Wanheng Li, Xuan Hou, Yiling Chen, Baicun Li, Ting Yang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Respiratory Research
Subjects:
Chronic obstructive pulmonary disease
Hypoxia
Cigarette smoke extract
HIF-1α
Alveolar macrophage homeostasis
Online Access:https://doi.org/10.1186/s12931-025-03303-9
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