Interfacial Engineering of Biocompatible Nanocapsules for Near‐Infrared‐Triggered Drug Release and Photothermal Therapy
Abstract Chemotherapy is an effective option for cancer treatment. However, its clinical application is often limited by the severe side effects of chemical drugs. To overcome these limitations, a novel drug‐loaded phase‐change nanocapsule system is developed. These nanocapsules are assembled via on...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202410844 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841543142740852736 |
|---|---|
| author | Yuting Xie Ze Yang Hang Shen Jingyi Chen David A. Weitz Dong Chen Jianpeng Sheng Tingbo Liang |
| author_facet | Yuting Xie Ze Yang Hang Shen Jingyi Chen David A. Weitz Dong Chen Jianpeng Sheng Tingbo Liang |
| author_sort | Yuting Xie |
| collection | DOAJ |
| description | Abstract Chemotherapy is an effective option for cancer treatment. However, its clinical application is often limited by the severe side effects of chemical drugs. To overcome these limitations, a novel drug‐loaded phase‐change nanocapsule system is developed. These nanocapsules are assembled via one‐step electrostatic self‐assembly through guided interfacial engineering. The phase change material core nanocapsules demonstrate great photothermal‐controlled drug release performance and exhibit excellent tumor‐targeting drug delivery performance both in vitro and in vivo via the binding of hyaluronic acid shell on the nanocapsule surface with corresponding receptors on the tumor cell membrane. The phototherapy function of the nanocapsules enhances immune activation within the tumor microenvironment, as demonstrated by flow cytometry and multiplex immunohistochemistry. The developed nanocapsules are biocompatible, versatile, and scalable and offer a promising smart delivery platform for controllable near‐infrared triggered drug release and photothermal therapy. |
| format | Article |
| id | doaj-art-4c5b6c84df8944e18ec57b92cd9eb0f8 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-4c5b6c84df8944e18ec57b92cd9eb0f82025-01-13T15:29:43ZengWileyAdvanced Science2198-38442025-01-01122n/an/a10.1002/advs.202410844Interfacial Engineering of Biocompatible Nanocapsules for Near‐Infrared‐Triggered Drug Release and Photothermal TherapyYuting Xie0Ze Yang1Hang Shen2Jingyi Chen3David A. Weitz4Dong Chen5Jianpeng Sheng6Tingbo Liang7Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 ChinaDepartment of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 ChinaDepartment of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 ChinaJohn A. Paulson School of Engineering and Applied Sciences Harvard University Cambridge MA 02138 USAJohn A. Paulson School of Engineering and Applied Sciences Harvard University Cambridge MA 02138 USADepartment of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 ChinaDepartment of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 ChinaDepartment of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 ChinaAbstract Chemotherapy is an effective option for cancer treatment. However, its clinical application is often limited by the severe side effects of chemical drugs. To overcome these limitations, a novel drug‐loaded phase‐change nanocapsule system is developed. These nanocapsules are assembled via one‐step electrostatic self‐assembly through guided interfacial engineering. The phase change material core nanocapsules demonstrate great photothermal‐controlled drug release performance and exhibit excellent tumor‐targeting drug delivery performance both in vitro and in vivo via the binding of hyaluronic acid shell on the nanocapsule surface with corresponding receptors on the tumor cell membrane. The phototherapy function of the nanocapsules enhances immune activation within the tumor microenvironment, as demonstrated by flow cytometry and multiplex immunohistochemistry. The developed nanocapsules are biocompatible, versatile, and scalable and offer a promising smart delivery platform for controllable near‐infrared triggered drug release and photothermal therapy.https://doi.org/10.1002/advs.202410844controlled releaseinterfacial engineeringnanocapsulenear‐infraredphototherapy |
| spellingShingle | Yuting Xie Ze Yang Hang Shen Jingyi Chen David A. Weitz Dong Chen Jianpeng Sheng Tingbo Liang Interfacial Engineering of Biocompatible Nanocapsules for Near‐Infrared‐Triggered Drug Release and Photothermal Therapy Advanced Science controlled release interfacial engineering nanocapsule near‐infrared phototherapy |
| title | Interfacial Engineering of Biocompatible Nanocapsules for Near‐Infrared‐Triggered Drug Release and Photothermal Therapy |
| title_full | Interfacial Engineering of Biocompatible Nanocapsules for Near‐Infrared‐Triggered Drug Release and Photothermal Therapy |
| title_fullStr | Interfacial Engineering of Biocompatible Nanocapsules for Near‐Infrared‐Triggered Drug Release and Photothermal Therapy |
| title_full_unstemmed | Interfacial Engineering of Biocompatible Nanocapsules for Near‐Infrared‐Triggered Drug Release and Photothermal Therapy |
| title_short | Interfacial Engineering of Biocompatible Nanocapsules for Near‐Infrared‐Triggered Drug Release and Photothermal Therapy |
| title_sort | interfacial engineering of biocompatible nanocapsules for near infrared triggered drug release and photothermal therapy |
| topic | controlled release interfacial engineering nanocapsule near‐infrared phototherapy |
| url | https://doi.org/10.1002/advs.202410844 |
| work_keys_str_mv | AT yutingxie interfacialengineeringofbiocompatiblenanocapsulesfornearinfraredtriggereddrugreleaseandphotothermaltherapy AT zeyang interfacialengineeringofbiocompatiblenanocapsulesfornearinfraredtriggereddrugreleaseandphotothermaltherapy AT hangshen interfacialengineeringofbiocompatiblenanocapsulesfornearinfraredtriggereddrugreleaseandphotothermaltherapy AT jingyichen interfacialengineeringofbiocompatiblenanocapsulesfornearinfraredtriggereddrugreleaseandphotothermaltherapy AT davidaweitz interfacialengineeringofbiocompatiblenanocapsulesfornearinfraredtriggereddrugreleaseandphotothermaltherapy AT dongchen interfacialengineeringofbiocompatiblenanocapsulesfornearinfraredtriggereddrugreleaseandphotothermaltherapy AT jianpengsheng interfacialengineeringofbiocompatiblenanocapsulesfornearinfraredtriggereddrugreleaseandphotothermaltherapy AT tingboliang interfacialengineeringofbiocompatiblenanocapsulesfornearinfraredtriggereddrugreleaseandphotothermaltherapy |