Ginsenoside Rb1 attenuates neuroflammation via activating Wnt/β-catenin signaling pathway to exert neuroprotective effect on cerebral ischemic-reperfusion injury

Ginsenoside Rb1 attenuates neuroflammation via activating Wnt/β-catenin signaling pathway to exert neuroprotective effect on cerebral ischemic-reperfusion injury

PurposeTo explore the molecular mechanism of G-Rb1 regulating microglia polarization through Wnt/β-catenin signaling pathway to alleviate cerebral ischemia-reperfusion injury in mice.MethodsC57BL/6J mouse middle cerebral artery occlusion/reperfusion (MCAO/R) model and microglia (BV2) oxygen-glucose...

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Bibliographic Details
Main Authors: Ruo-jing Liu, Xue Zhao, Yi-zhen Zhu, Ling-Ling Fu, Guo Ge, Jun-de Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
ginsenoside Rb1
Wnt/β-catenin signaling pathway
microglia polarization
neuroinflammation
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1555067/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1555067/full

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