Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells
An external trauma, illness, or other pathological cause can harm the structure and function of the spinal cord, resulting in a significant neurological disorder known as spinal cord injury (SCI). In addition to impairing movement and sensory functions, spinal cord injury (SCI) triggers complex path...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1505755/full |
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| author | Jian Li Xiaolei Zhai Chaochun Yu |
| author_facet | Jian Li Xiaolei Zhai Chaochun Yu |
| author_sort | Jian Li |
| collection | DOAJ |
| description | An external trauma, illness, or other pathological cause can harm the structure and function of the spinal cord, resulting in a significant neurological disorder known as spinal cord injury (SCI). In addition to impairing movement and sensory functions, spinal cord injury (SCI) triggers complex pathophysiological responses, with the spatial dynamics of immune cells playing a key role. The inflammatory response and subsequent healing processes following SCI are profoundly influenced by the spatial distribution and movement of immune cells. Despite significant advances in both scientific and clinical research, SCI therapy still faces several challenges. These challenges primarily stem from our limited understanding of the spatial dynamics of immune cell distribution and the processes that regulate their interactions within the microenvironment following injury. Therefore, a comprehensive investigation into the spatial dynamics of immune cells following SCI is essential to uncover their mechanisms in neuroinflammation and repair, and to develop novel therapeutic strategies. |
| format | Article |
| id | doaj-art-4c41db7c408a4d2080a2bb4bec744eac |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-4c41db7c408a4d2080a2bb4bec744eac2025-01-09T05:10:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15057551505755Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cellsJian Li0Xiaolei Zhai1Chaochun Yu2Shanghai TCM-Integrated Hospital, Shanghai University of TCM, Department of Neurosurgery, Shanghai, ChinaDepartment of Neurosurgery, Shuyang Hospital of Traditional Chinese Medicine, Affiliated Shuyang Hospital of Nanjing University of Chinese Medicine, Shuyang, ChinaShanghai TCM-Integrated Hospital, Shanghai University of TCM, Department of Neurosurgery, Shanghai, ChinaAn external trauma, illness, or other pathological cause can harm the structure and function of the spinal cord, resulting in a significant neurological disorder known as spinal cord injury (SCI). In addition to impairing movement and sensory functions, spinal cord injury (SCI) triggers complex pathophysiological responses, with the spatial dynamics of immune cells playing a key role. The inflammatory response and subsequent healing processes following SCI are profoundly influenced by the spatial distribution and movement of immune cells. Despite significant advances in both scientific and clinical research, SCI therapy still faces several challenges. These challenges primarily stem from our limited understanding of the spatial dynamics of immune cell distribution and the processes that regulate their interactions within the microenvironment following injury. Therefore, a comprehensive investigation into the spatial dynamics of immune cells following SCI is essential to uncover their mechanisms in neuroinflammation and repair, and to develop novel therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1505755/fullspinal cord injurypathologyneuroimmune cellsprogressionspatial distributionimmune cells |
| spellingShingle | Jian Li Xiaolei Zhai Chaochun Yu Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells Frontiers in Immunology spinal cord injury pathology neuroimmune cells progression spatial distribution immune cells |
| title | Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells |
| title_full | Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells |
| title_fullStr | Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells |
| title_full_unstemmed | Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells |
| title_short | Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells |
| title_sort | spatial distribution based progression of spinal cord injury pathology a key role for neuroimmune cells |
| topic | spinal cord injury pathology neuroimmune cells progression spatial distribution immune cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1505755/full |
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