Injectable magnesium-bisphosphonate MOF-based bone adhesive prevents excessive fibrosis for osteoporotic fracture repair

Injectable magnesium-bisphosphonate MOF-based bone adhesive prevents excessive fibrosis for osteoporotic fracture repair

Abstract Current treatments for osteoporotic fractures primarily target bone-resorbing osteoclasts, but they often fail to address fibrosis—a buildup of fibrous tissue that disrupts bone healing. This fibrosis is frequently triggered by bisphosphonates, which, while effective in reducing bone loss,...

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Main Authors: Tianhua Xiao, Zunlei Gong, Dongming Duan, Hui Yu, Song Liu, Yuhe Jiang, Xudan Xing, Zenghui Wu, Le Wang, Xuebin B. Yang, Giuseppe Tronci, Chengyun Ning, Guoxin Tan, Lei Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60853-8
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