The role of major virulence factors and pathogenicity of adherent-invasive Escherichia coli in patients with Crohn’s disease
Inflammatory bowel disease (IBD) is a term that describes Crohn’s disease (CD) and ulcerative colitis (UC), and these two conditions are characterised by chronic inflammation of the gastrointestinal tract. Dysbiosis of intestinal microbiota has been consistently linked to patients with IBD. In the l...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2020-12-01
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| Series: | Gastroenterology Review |
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| Online Access: | https://www.termedia.pl/The-role-of-major-virulence-factors-and-pathogenicity-r-nof-adherent-invasive-Escherichia-coli-in-patients-with-r-nCrohn-s-disease,41,39966,1,1.html |
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| _version_ | 1841548302782300160 |
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| author | Khalid A. Abdelhalim Ataç Uzel Nalan Gülşen Ünal |
| author_facet | Khalid A. Abdelhalim Ataç Uzel Nalan Gülşen Ünal |
| author_sort | Khalid A. Abdelhalim |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a term that describes Crohn’s disease (CD) and ulcerative colitis (UC), and these two conditions are characterised by chronic inflammation of the gastrointestinal tract. Dysbiosis of intestinal microbiota has been consistently linked to patients with IBD. In the last two decades, the progressive implication of adherent-invasive Escherichia coli (AIEC) pathogenesis in patients with CD has been increasing. Here we discuss recent findings that indicate the role and mechanisms of AIEC in IBD. We also highlight AIEC virulence factor genes and mechanisms that suggest an important role in the severity of inflammation in CD patients. Finally, we emphasise data on the prevalence of AIEC in CD patients. |
| format | Article |
| id | doaj-art-4c051ce2225d47c0950036b227016703 |
| institution | Kabale University |
| issn | 1895-5770 1897-4317 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Gastroenterology Review |
| spelling | doaj-art-4c051ce2225d47c0950036b2270167032025-01-10T14:06:17ZengTermedia Publishing HouseGastroenterology Review1895-57701897-43172020-12-0115427928810.5114/pg.2020.9323539966The role of major virulence factors and pathogenicity of adherent-invasive Escherichia coli in patients with Crohn’s diseaseKhalid A. AbdelhalimAtaç UzelNalan Gülşen ÜnalInflammatory bowel disease (IBD) is a term that describes Crohn’s disease (CD) and ulcerative colitis (UC), and these two conditions are characterised by chronic inflammation of the gastrointestinal tract. Dysbiosis of intestinal microbiota has been consistently linked to patients with IBD. In the last two decades, the progressive implication of adherent-invasive Escherichia coli (AIEC) pathogenesis in patients with CD has been increasing. Here we discuss recent findings that indicate the role and mechanisms of AIEC in IBD. We also highlight AIEC virulence factor genes and mechanisms that suggest an important role in the severity of inflammation in CD patients. Finally, we emphasise data on the prevalence of AIEC in CD patients.https://www.termedia.pl/The-role-of-major-virulence-factors-and-pathogenicity-r-nof-adherent-invasive-Escherichia-coli-in-patients-with-r-nCrohn-s-disease,41,39966,1,1.htmladherent-invasive escherichia coli escherichia coli crohn’s disease inflammatory bowel disease virulence factors. |
| spellingShingle | Khalid A. Abdelhalim Ataç Uzel Nalan Gülşen Ünal The role of major virulence factors and pathogenicity of adherent-invasive Escherichia coli in patients with Crohn’s disease Gastroenterology Review adherent-invasive escherichia coli escherichia coli crohn’s disease inflammatory bowel disease virulence factors. |
| title | The role of major virulence factors and pathogenicity
of adherent-invasive Escherichia coli in patients with
Crohn’s disease |
| title_full | The role of major virulence factors and pathogenicity
of adherent-invasive Escherichia coli in patients with
Crohn’s disease |
| title_fullStr | The role of major virulence factors and pathogenicity
of adherent-invasive Escherichia coli in patients with
Crohn’s disease |
| title_full_unstemmed | The role of major virulence factors and pathogenicity
of adherent-invasive Escherichia coli in patients with
Crohn’s disease |
| title_short | The role of major virulence factors and pathogenicity
of adherent-invasive Escherichia coli in patients with
Crohn’s disease |
| title_sort | role of major virulence factors and pathogenicity of adherent invasive escherichia coli in patients with crohn s disease |
| topic | adherent-invasive escherichia coli escherichia coli crohn’s disease inflammatory bowel disease virulence factors. |
| url | https://www.termedia.pl/The-role-of-major-virulence-factors-and-pathogenicity-r-nof-adherent-invasive-Escherichia-coli-in-patients-with-r-nCrohn-s-disease,41,39966,1,1.html |
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