Naringenin may prevent morphine-induced tolerance via inhibiting glycogen synthase kinase-3beta activity in mice

Naringenin may prevent morphine-induced tolerance via inhibiting glycogen synthase kinase-3beta activity in mice

Background: Opioids are essential for pain treatment, but their long-term usage results in tolerance. Naringenin, a natural flavonoid found in fruit, inhibits the enzyme that causes opioid tolerance, making it effective in treating neurodegenerative diseases. Objective: In this study, we evaluate th...

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Bibliographic Details
Main Authors: Samira Shirooie, Seyed Kimia Jasemi, Golale Babaei, Mohammad Reza Morovati, Maryam Ghanbari-Movahed, Saman Barzegar, Mohammad Hosein Farzaei
Format: Article
Language:English
Published: Institue of Medicinal Plants, ACECR 2024-03-01
Series:Journal of Medicinal Plants
Subjects:
naringenin
gsk
p-gsser640
tolerance to morphine
opioids
animal model
Online Access:http://jmp.ir/article-1-3653-en.pdf
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