Installation of an Indole on the BRCA1 Disordered Domain Using Triazine Chemistry

Installation of an Indole on the BRCA1 Disordered Domain Using Triazine Chemistry

The functionalization of protein sidechains with highly water-soluble chlorotriazines (or derivatives thereof) using nucleophilic aromatic substitution reactions has been commonly employed to install various functional groups, including poly(ethylene glycol) tags or fluorogenic labels. Here, a poorl...

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Bibliographic Details
Main Authors: Liam E. Claton, Chrissy Baker, Hayes Martin, Sergei V. Dzyuba, Khadiza Zaman, Laszlo Prokai, Mikaela D. Stewart, Eric E. Simanek
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomolecules
Subjects:
protein labeling
BRCA1
indole
fluorescent labels
protein modification
triazine
Online Access:https://www.mdpi.com/2218-273X/14/12/1625
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