Effect of radionuclide activity concentration on PET-CT image uniformity
Assessment of radionuclide activity concentration on positron emission tomography-computedr tomography (PET-CT) image uniformity has been carried out quantitatively. Tomographic PET-CT images of cylindrical phantom containing F-18 fluorodeoxyglucose (FDG) activity concentration was acquired and used...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2016-04-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.167578 |
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| author | Francis Hasford Bronwin Wyk Thulani Mabhengu Mboyo Vangu Augustine Kyere John Amuasi |
| author_facet | Francis Hasford Bronwin Wyk Thulani Mabhengu Mboyo Vangu Augustine Kyere John Amuasi |
| author_sort | Francis Hasford |
| collection | DOAJ |
| description | Assessment of radionuclide activity concentration on positron emission tomography-computedr tomography (PET-CT) image uniformity has been carried out quantitatively. Tomographic PET-CT images of cylindrical phantom containing F-18 fluorodeoxyglucose (FDG) activity concentration was acquired and used for the assessment. Activity concentrations were varied and PET-CT images were acquired at the constant acquisition parameters of time, matrix size, and reconstruction algorithm, respectively. Using midtransaxial image slices, quantitative index of nonuniformity (NU), and coefficient of uniformity variation were estimated for the different activity concentrations. Maximum NUs of 17.6%, 26.3%, 32.7%, 36.2%, and 38.5% were estimated for activity concentrations of 16.87 kBq/mL, 14.06 kBq/mL, 11.25 kBq/mL, 8.43 kBq/mL, and 5.62 kBq/mL, respectively. The coefficient of uniformity variation established an inverse quadratic relationship with activity concentration. Activity concentrations of 16.87 kBq/mL, 14.06 kBq/mL, 11.25 kBq/mL, 8.43 kBq/mL, and 5.62 kBq/mL produced uniformity variations of 1.47%, 2.52%, 4.23%, 5.12%, and 4.98%, respectively. Increasing activity concentration resulted in decreasing coefficient of uniformity and hence, an increase in image uniformity. The uniformity estimates compared well with the standards set internationally. |
| format | Article |
| id | doaj-art-4be4d3bc167b4d7da4b83f97ee00b544 |
| institution | Kabale University |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2016-04-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-4be4d3bc167b4d7da4b83f97ee00b5442025-08-20T03:48:36ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122016-04-011502919510.4103/1450-1147.167578Effect of radionuclide activity concentration on PET-CT image uniformityFrancis Hasford0Bronwin Wyk1Thulani Mabhengu2Mboyo Vangu3Augustine Kyere4John Amuasi5Department of Nuclear Medicine, CM Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South AfricaDepartment of Nuclear Medicine, CM Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South AfricaDepartment of Nuclear Medicine, CM Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South AfricaDepartment of Nuclear Medicine, CM Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South AfricaDepartment of Medical Physics, School of Nuclear and Allied Sciences, University of Ghana, Accra, GhanaDepartment of Medical Physics, School of Nuclear and Allied Sciences, University of Ghana, Accra, GhanaAssessment of radionuclide activity concentration on positron emission tomography-computedr tomography (PET-CT) image uniformity has been carried out quantitatively. Tomographic PET-CT images of cylindrical phantom containing F-18 fluorodeoxyglucose (FDG) activity concentration was acquired and used for the assessment. Activity concentrations were varied and PET-CT images were acquired at the constant acquisition parameters of time, matrix size, and reconstruction algorithm, respectively. Using midtransaxial image slices, quantitative index of nonuniformity (NU), and coefficient of uniformity variation were estimated for the different activity concentrations. Maximum NUs of 17.6%, 26.3%, 32.7%, 36.2%, and 38.5% were estimated for activity concentrations of 16.87 kBq/mL, 14.06 kBq/mL, 11.25 kBq/mL, 8.43 kBq/mL, and 5.62 kBq/mL, respectively. The coefficient of uniformity variation established an inverse quadratic relationship with activity concentration. Activity concentrations of 16.87 kBq/mL, 14.06 kBq/mL, 11.25 kBq/mL, 8.43 kBq/mL, and 5.62 kBq/mL produced uniformity variations of 1.47%, 2.52%, 4.23%, 5.12%, and 4.98%, respectively. Increasing activity concentration resulted in decreasing coefficient of uniformity and hence, an increase in image uniformity. The uniformity estimates compared well with the standards set internationally.http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.167578activity concentrationcounts of activityimage uniformitypositron emission tomography-computed tomographyradionuclide |
| spellingShingle | Francis Hasford Bronwin Wyk Thulani Mabhengu Mboyo Vangu Augustine Kyere John Amuasi Effect of radionuclide activity concentration on PET-CT image uniformity World Journal of Nuclear Medicine activity concentration counts of activity image uniformity positron emission tomography-computed tomography radionuclide |
| title | Effect of radionuclide activity concentration on PET-CT image uniformity |
| title_full | Effect of radionuclide activity concentration on PET-CT image uniformity |
| title_fullStr | Effect of radionuclide activity concentration on PET-CT image uniformity |
| title_full_unstemmed | Effect of radionuclide activity concentration on PET-CT image uniformity |
| title_short | Effect of radionuclide activity concentration on PET-CT image uniformity |
| title_sort | effect of radionuclide activity concentration on pet ct image uniformity |
| topic | activity concentration counts of activity image uniformity positron emission tomography-computed tomography radionuclide |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.167578 |
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