The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy
Colorectal cancer (CRC) is one of the most prevalent and deadly malignancies worldwide. Recently, ferroptosis, a novel form of regulated cell death characterized by iron dependency and lipid peroxidation, has garnered significant attention from researchers. The mechanisms underlying ferroptosis, inc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1526749/full |
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| author | Wenhua Xia Wenhua Xia Yuanhao Lv Yuanhao Lv Yan Zou Zhanting Kang Zhaoyi Li Jiaqi Tian Hongyan Zhou Wei Su Wei Su Jiateng Zhong Jiateng Zhong Jiateng Zhong Jiateng Zhong |
| author_facet | Wenhua Xia Wenhua Xia Yuanhao Lv Yuanhao Lv Yan Zou Zhanting Kang Zhaoyi Li Jiaqi Tian Hongyan Zhou Wei Su Wei Su Jiateng Zhong Jiateng Zhong Jiateng Zhong Jiateng Zhong |
| author_sort | Wenhua Xia |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the most prevalent and deadly malignancies worldwide. Recently, ferroptosis, a novel form of regulated cell death characterized by iron dependency and lipid peroxidation, has garnered significant attention from researchers. The mechanisms underlying ferroptosis, including intracellular iron levels, lipid peroxidation, and antioxidant system regulation, offer new insights into cancer treatment strategies. This study aims to explore the emerging role of ferroptosis in the context of immunotherapy for CRC, highlighting its potential mechanisms and clinical applications. We employed a comprehensive review of current literature to elucidate the biological mechanisms of ferroptosis, its relationship with CRC, and the interplay between ferroptosis and immunotherapy. Ferroptosis reshapes the tumor microenvironment (TME) by regulating intracellular iron levels, lipid metabolism, and antioxidant systems, significantly enhancing the efficacy of immune checkpoint inhibitors (ICIs). Meanwhile, traditional Chinese medicine therapies promote antitumor immunity by modulating the TME and inducing ferroptosis. Additionally, advances in nanotechnology have facilitated precise therapy by enabling targeted delivery of ferroptosis inducers or immunomodulators, transforming “cold” tumors into “hot” tumors and further boosting ICI efficacy. This study comprehensively reviews the latest developments in ferroptosis, immunotherapy, traditional Chinese medicine, and nanotechnology in CRC, highlighting the importance of ferroptosis-related biomarkers and novel inducers for personalized treatment. In summary, ferroptosis offers a promising strategy to overcome CRC therapy resistance and enhance immunotherapy efficacy, warranting further investigation and translational application. |
| format | Article |
| id | doaj-art-4bd535575e864ccd82acd8e9b35b1b7e |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-4bd535575e864ccd82acd8e9b35b1b7e2025-01-09T06:11:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15267491526749The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapyWenhua Xia0Wenhua Xia1Yuanhao Lv2Yuanhao Lv3Yan Zou4Zhanting Kang5Zhaoyi Li6Jiaqi Tian7Hongyan Zhou8Wei Su9Wei Su10Jiateng Zhong11Jiateng Zhong12Jiateng Zhong13Jiateng Zhong14Department of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaDepartment of Pathology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaDepartment of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaDepartment of Pathology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaDepartment of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaDepartment of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaDepartment of Pathology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaDepartment of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaXinxiang Key Laboratory of Precision Diagnosis and Treatment for Colorectal Cancer, Xinxiang First People’s Hospital, Xinxiang, ChinaDepartment of Pathology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaXinxiang Engineering Technology Research Center of Digestive Tumor Molecular Diagnosis, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaDepartment of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaDepartment of Pathology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaXinxiang Key Laboratory of Precision Diagnosis and Treatment for Colorectal Cancer, Xinxiang First People’s Hospital, Xinxiang, ChinaXinxiang Engineering Technology Research Center of Digestive Tumor Molecular Diagnosis, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaColorectal cancer (CRC) is one of the most prevalent and deadly malignancies worldwide. Recently, ferroptosis, a novel form of regulated cell death characterized by iron dependency and lipid peroxidation, has garnered significant attention from researchers. The mechanisms underlying ferroptosis, including intracellular iron levels, lipid peroxidation, and antioxidant system regulation, offer new insights into cancer treatment strategies. This study aims to explore the emerging role of ferroptosis in the context of immunotherapy for CRC, highlighting its potential mechanisms and clinical applications. We employed a comprehensive review of current literature to elucidate the biological mechanisms of ferroptosis, its relationship with CRC, and the interplay between ferroptosis and immunotherapy. Ferroptosis reshapes the tumor microenvironment (TME) by regulating intracellular iron levels, lipid metabolism, and antioxidant systems, significantly enhancing the efficacy of immune checkpoint inhibitors (ICIs). Meanwhile, traditional Chinese medicine therapies promote antitumor immunity by modulating the TME and inducing ferroptosis. Additionally, advances in nanotechnology have facilitated precise therapy by enabling targeted delivery of ferroptosis inducers or immunomodulators, transforming “cold” tumors into “hot” tumors and further boosting ICI efficacy. This study comprehensively reviews the latest developments in ferroptosis, immunotherapy, traditional Chinese medicine, and nanotechnology in CRC, highlighting the importance of ferroptosis-related biomarkers and novel inducers for personalized treatment. In summary, ferroptosis offers a promising strategy to overcome CRC therapy resistance and enhance immunotherapy efficacy, warranting further investigation and translational application.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1526749/fullferroptosiscolorectal cancerimmunotherapyimmune checkpoint inhibitors (ICBs)tumor microenvironment |
| spellingShingle | Wenhua Xia Wenhua Xia Yuanhao Lv Yuanhao Lv Yan Zou Zhanting Kang Zhaoyi Li Jiaqi Tian Hongyan Zhou Wei Su Wei Su Jiateng Zhong Jiateng Zhong Jiateng Zhong Jiateng Zhong The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy Frontiers in Immunology ferroptosis colorectal cancer immunotherapy immune checkpoint inhibitors (ICBs) tumor microenvironment |
| title | The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy |
| title_full | The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy |
| title_fullStr | The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy |
| title_full_unstemmed | The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy |
| title_short | The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy |
| title_sort | role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy |
| topic | ferroptosis colorectal cancer immunotherapy immune checkpoint inhibitors (ICBs) tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1526749/full |
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