Bile acid-mediated gut-liver axis crosstalk: the role of nuclear receptor signaling in dynamic regulation of inflammatory networks

Bile acid-mediated gut-liver axis crosstalk: the role of nuclear receptor signaling in dynamic regulation of inflammatory networks

Bile acids (BAs) are critical mediators of metabolic and immune regulation, influencing both liver and intestinal function. Their homeostasis, maintained through the enterohepatic circulation, is pivotal for immune-metabolic balance. BAs activate key receptors, including Farnesoid X Receptor (FXR) a...

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Bibliographic Details
Main Authors: Wenlong Yan, Kun Zhang, Jing Guo, Lingfen Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
bile acid metabolism
gut-liver axis
FXR
TGR5
inflammatory network
intestinal flora
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1595486/full
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