Eradication Therapy Should Be Different for Dyspeptic Patients than for Ulcer Patients
Physicians should try to achieve an optimal cure rate with their initial Helicobacter pylori eradication therapy. Most physicians use the same treatment in all their patients. H pylori infection in patients with peptic ulcer disease (PUD) is more likely to be cured than that in patients with functio...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2003-01-01
|
| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2003/136716 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849412899079979008 |
|---|---|
| author | Wink A de Boer |
| author_facet | Wink A de Boer |
| author_sort | Wink A de Boer |
| collection | DOAJ |
| description | Physicians should try to achieve an optimal cure rate with their initial
Helicobacter pylori eradication therapy. Most physicians use the
same treatment in all their patients. H pylori infection in patients
with peptic ulcer disease (PUD) is more likely to be cured than that
in patients with functional dyspepsia (FD). Differences in cure rates
of 5% to 15% are usually reported, which is considered to be clinically
relevant. A plausible biological explanation for this finding suggests
that different strains (virulent [cagA+, vacA type s1] compared
with nonvirulent strains [cagA–, vacA type s2]) in PUD and FD
induce different changes in the gastric mucosa, and this facilitates or
impairs antimicrobial efficacy. Physicians should be aware that most
published treatment studies have included only PUD patients. This
means that in clinical practice cure rates obtained in patients with
FD or perhaps uninvestigated dyspepsia are usually lower than those
reported in the literature. This has implications for the choice of
treatment. Physicians should consider prolonging the duration of initial
Helicobacter eradication therapy from seven to 10 to 14 days in
patients without ulcers. |
| format | Article |
| id | doaj-art-4ba6d5f3057d4dba9e1f17d56ad9be47 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-4ba6d5f3057d4dba9e1f17d56ad9be472025-08-20T03:34:18ZengWileyCanadian Journal of Gastroenterology0835-79002003-01-0117Suppl B41B45B10.1155/2003/136716Eradication Therapy Should Be Different for Dyspeptic Patients than for Ulcer PatientsWink A de Boer0Bernhoven Hospital, Oss, NetherlandsPhysicians should try to achieve an optimal cure rate with their initial Helicobacter pylori eradication therapy. Most physicians use the same treatment in all their patients. H pylori infection in patients with peptic ulcer disease (PUD) is more likely to be cured than that in patients with functional dyspepsia (FD). Differences in cure rates of 5% to 15% are usually reported, which is considered to be clinically relevant. A plausible biological explanation for this finding suggests that different strains (virulent [cagA+, vacA type s1] compared with nonvirulent strains [cagA–, vacA type s2]) in PUD and FD induce different changes in the gastric mucosa, and this facilitates or impairs antimicrobial efficacy. Physicians should be aware that most published treatment studies have included only PUD patients. This means that in clinical practice cure rates obtained in patients with FD or perhaps uninvestigated dyspepsia are usually lower than those reported in the literature. This has implications for the choice of treatment. Physicians should consider prolonging the duration of initial Helicobacter eradication therapy from seven to 10 to 14 days in patients without ulcers.http://dx.doi.org/10.1155/2003/136716 |
| spellingShingle | Wink A de Boer Eradication Therapy Should Be Different for Dyspeptic Patients than for Ulcer Patients Canadian Journal of Gastroenterology |
| title | Eradication Therapy Should Be Different for Dyspeptic Patients than for Ulcer Patients |
| title_full | Eradication Therapy Should Be Different for Dyspeptic Patients than for Ulcer Patients |
| title_fullStr | Eradication Therapy Should Be Different for Dyspeptic Patients than for Ulcer Patients |
| title_full_unstemmed | Eradication Therapy Should Be Different for Dyspeptic Patients than for Ulcer Patients |
| title_short | Eradication Therapy Should Be Different for Dyspeptic Patients than for Ulcer Patients |
| title_sort | eradication therapy should be different for dyspeptic patients than for ulcer patients |
| url | http://dx.doi.org/10.1155/2003/136716 |
| work_keys_str_mv | AT winkadeboer eradicationtherapyshouldbedifferentfordyspepticpatientsthanforulcerpatients |