The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients

Background: Cutaneous leishmaniasis (CL) is a dermatological condition that arises due to the presence of protozoan parasites. The disease disproportionately impacts those residing in economically disadvantaged regions and is closely linked to factors such as inadequate nutrition, population displac...

Full description

Saved in:
Bibliographic Details
Main Authors: Abrar Kareem Dhari, Ali Mohammed Abed, Suha Maher Abed
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-10-01
Series:Medical Journal of Babylon
Subjects:
Online Access:https://doi.org/10.4103/MJBL.MJBL_1202_23
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1841536787094175744
author Abrar Kareem Dhari
Ali Mohammed Abed
Suha Maher Abed
author_facet Abrar Kareem Dhari
Ali Mohammed Abed
Suha Maher Abed
author_sort Abrar Kareem Dhari
collection DOAJ
description Background: Cutaneous leishmaniasis (CL) is a dermatological condition that arises due to the presence of protozoan parasites. The disease disproportionately impacts those residing in economically disadvantaged regions and is closely linked to factors such as inadequate nutrition, population displacement, substandard living conditions, and compromised immune systems. Objectives: Investigating the most important immunological changes associated with infection in patients with CL by measuring the levels of some cellular kinetics interleukins-12 (IL-12), IL-10, IL-4, and human matrix metalloproteinase-13 (MMP-13). Materials and Methods: This study involved a sample that included 90 individuals, comprising 20 control subjects and 70 patients diagnosed with CL. The age distribution of the participants in the study spanned from 3 months to 65 years, encompassing individuals of both genders. The sample consisted of 50 females and 40 males. The amounts of IL-12, IL-10, IL-4, and MMP-13 were quantified via an enzyme-linked immunosorbent assay (ELISA) test. Results: The current study showed a significant increase in the level of IL-12 in patients with CL (461.5 ± 14.8) compared to the control group (321.6 ± 57.9) at probability 0.05, whereas non-significant differences in levels of IL-10 and MMP-13 in patients with CL (143.5 ± 6.8) (5.7 ± 0.2) compared with the control group (198.0 ± 35.2) (6.9 ± 0.6) at P ≤ 0.05, respectively. As well as a highly significant decrease in the level of IL-4 in patients with CL (15.5 ± 1.5) compared to the control group (46.3 ± 5.7) at P ≤ 0.05. Conclusion: There was an increasing serum of IL-12 and decreased IL-4 in patients with CL compared with control, while non-significant decreases in the level of MMP-13 and IL-10 between patients with CL and control.
format Article
id doaj-art-4ba6a3d864024bb99a05e96e75eccdcc
institution Kabale University
issn 1812-156X
2312-6760
language English
publishDate 2024-10-01
publisher Wolters Kluwer Medknow Publications
record_format Article
series Medical Journal of Babylon
spelling doaj-art-4ba6a3d864024bb99a05e96e75eccdcc2025-01-14T11:24:47ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602024-10-0121Suppl 2S244S24910.4103/MJBL.MJBL_1202_23The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patientsAbrar Kareem DhariAli Mohammed AbedSuha Maher AbedBackground: Cutaneous leishmaniasis (CL) is a dermatological condition that arises due to the presence of protozoan parasites. The disease disproportionately impacts those residing in economically disadvantaged regions and is closely linked to factors such as inadequate nutrition, population displacement, substandard living conditions, and compromised immune systems. Objectives: Investigating the most important immunological changes associated with infection in patients with CL by measuring the levels of some cellular kinetics interleukins-12 (IL-12), IL-10, IL-4, and human matrix metalloproteinase-13 (MMP-13). Materials and Methods: This study involved a sample that included 90 individuals, comprising 20 control subjects and 70 patients diagnosed with CL. The age distribution of the participants in the study spanned from 3 months to 65 years, encompassing individuals of both genders. The sample consisted of 50 females and 40 males. The amounts of IL-12, IL-10, IL-4, and MMP-13 were quantified via an enzyme-linked immunosorbent assay (ELISA) test. Results: The current study showed a significant increase in the level of IL-12 in patients with CL (461.5 ± 14.8) compared to the control group (321.6 ± 57.9) at probability 0.05, whereas non-significant differences in levels of IL-10 and MMP-13 in patients with CL (143.5 ± 6.8) (5.7 ± 0.2) compared with the control group (198.0 ± 35.2) (6.9 ± 0.6) at P ≤ 0.05, respectively. As well as a highly significant decrease in the level of IL-4 in patients with CL (15.5 ± 1.5) compared to the control group (46.3 ± 5.7) at P ≤ 0.05. Conclusion: There was an increasing serum of IL-12 and decreased IL-4 in patients with CL compared with control, while non-significant decreases in the level of MMP-13 and IL-10 between patients with CL and control.https://doi.org/10.4103/MJBL.MJBL_1202_23cutaneous leishmaniasisil-10il-12il-4human matrix metalloproteinase-13 (mmp-13)
spellingShingle Abrar Kareem Dhari
Ali Mohammed Abed
Suha Maher Abed
The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients
Medical Journal of Babylon
cutaneous leishmaniasis
il-10
il-12
il-4
human matrix metalloproteinase-13 (mmp-13)
title The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients
title_full The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients
title_fullStr The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients
title_full_unstemmed The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients
title_short The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients
title_sort level of il 12 il 10 il 4 and mmp 13 in cutaneous leishmaniasis patients
topic cutaneous leishmaniasis
il-10
il-12
il-4
human matrix metalloproteinase-13 (mmp-13)
url https://doi.org/10.4103/MJBL.MJBL_1202_23
work_keys_str_mv AT abrarkareemdhari thelevelofil12il10il4andmmp13incutaneousleishmaniasispatients
AT alimohammedabed thelevelofil12il10il4andmmp13incutaneousleishmaniasispatients
AT suhamaherabed thelevelofil12il10il4andmmp13incutaneousleishmaniasispatients
AT abrarkareemdhari levelofil12il10il4andmmp13incutaneousleishmaniasispatients
AT alimohammedabed levelofil12il10il4andmmp13incutaneousleishmaniasispatients
AT suhamaherabed levelofil12il10il4andmmp13incutaneousleishmaniasispatients