The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients
Background: Cutaneous leishmaniasis (CL) is a dermatological condition that arises due to the presence of protozoan parasites. The disease disproportionately impacts those residing in economically disadvantaged regions and is closely linked to factors such as inadequate nutrition, population displac...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Medical Journal of Babylon |
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| Online Access: | https://doi.org/10.4103/MJBL.MJBL_1202_23 |
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| author | Abrar Kareem Dhari Ali Mohammed Abed Suha Maher Abed |
| author_facet | Abrar Kareem Dhari Ali Mohammed Abed Suha Maher Abed |
| author_sort | Abrar Kareem Dhari |
| collection | DOAJ |
| description | Background: Cutaneous leishmaniasis (CL) is a dermatological condition that arises due to the presence of protozoan parasites. The disease disproportionately impacts those residing in economically disadvantaged regions and is closely linked to factors such as inadequate nutrition, population displacement, substandard living conditions, and compromised immune systems. Objectives: Investigating the most important immunological changes associated with infection in patients with CL by measuring the levels of some cellular kinetics interleukins-12 (IL-12), IL-10, IL-4, and human matrix metalloproteinase-13 (MMP-13). Materials and Methods: This study involved a sample that included 90 individuals, comprising 20 control subjects and 70 patients diagnosed with CL. The age distribution of the participants in the study spanned from 3 months to 65 years, encompassing individuals of both genders. The sample consisted of 50 females and 40 males. The amounts of IL-12, IL-10, IL-4, and MMP-13 were quantified via an enzyme-linked immunosorbent assay (ELISA) test. Results: The current study showed a significant increase in the level of IL-12 in patients with CL (461.5 ± 14.8) compared to the control group (321.6 ± 57.9) at probability 0.05, whereas non-significant differences in levels of IL-10 and MMP-13 in patients with CL (143.5 ± 6.8) (5.7 ± 0.2) compared with the control group (198.0 ± 35.2) (6.9 ± 0.6) at P ≤ 0.05, respectively. As well as a highly significant decrease in the level of IL-4 in patients with CL (15.5 ± 1.5) compared to the control group (46.3 ± 5.7) at P ≤ 0.05. Conclusion: There was an increasing serum of IL-12 and decreased IL-4 in patients with CL compared with control, while non-significant decreases in the level of MMP-13 and IL-10 between patients with CL and control. |
| format | Article |
| id | doaj-art-4ba6a3d864024bb99a05e96e75eccdcc |
| institution | Kabale University |
| issn | 1812-156X 2312-6760 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj-art-4ba6a3d864024bb99a05e96e75eccdcc2025-01-14T11:24:47ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602024-10-0121Suppl 2S244S24910.4103/MJBL.MJBL_1202_23The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patientsAbrar Kareem DhariAli Mohammed AbedSuha Maher AbedBackground: Cutaneous leishmaniasis (CL) is a dermatological condition that arises due to the presence of protozoan parasites. The disease disproportionately impacts those residing in economically disadvantaged regions and is closely linked to factors such as inadequate nutrition, population displacement, substandard living conditions, and compromised immune systems. Objectives: Investigating the most important immunological changes associated with infection in patients with CL by measuring the levels of some cellular kinetics interleukins-12 (IL-12), IL-10, IL-4, and human matrix metalloproteinase-13 (MMP-13). Materials and Methods: This study involved a sample that included 90 individuals, comprising 20 control subjects and 70 patients diagnosed with CL. The age distribution of the participants in the study spanned from 3 months to 65 years, encompassing individuals of both genders. The sample consisted of 50 females and 40 males. The amounts of IL-12, IL-10, IL-4, and MMP-13 were quantified via an enzyme-linked immunosorbent assay (ELISA) test. Results: The current study showed a significant increase in the level of IL-12 in patients with CL (461.5 ± 14.8) compared to the control group (321.6 ± 57.9) at probability 0.05, whereas non-significant differences in levels of IL-10 and MMP-13 in patients with CL (143.5 ± 6.8) (5.7 ± 0.2) compared with the control group (198.0 ± 35.2) (6.9 ± 0.6) at P ≤ 0.05, respectively. As well as a highly significant decrease in the level of IL-4 in patients with CL (15.5 ± 1.5) compared to the control group (46.3 ± 5.7) at P ≤ 0.05. Conclusion: There was an increasing serum of IL-12 and decreased IL-4 in patients with CL compared with control, while non-significant decreases in the level of MMP-13 and IL-10 between patients with CL and control.https://doi.org/10.4103/MJBL.MJBL_1202_23cutaneous leishmaniasisil-10il-12il-4human matrix metalloproteinase-13 (mmp-13) |
| spellingShingle | Abrar Kareem Dhari Ali Mohammed Abed Suha Maher Abed The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients Medical Journal of Babylon cutaneous leishmaniasis il-10 il-12 il-4 human matrix metalloproteinase-13 (mmp-13) |
| title | The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients |
| title_full | The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients |
| title_fullStr | The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients |
| title_full_unstemmed | The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients |
| title_short | The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients |
| title_sort | level of il 12 il 10 il 4 and mmp 13 in cutaneous leishmaniasis patients |
| topic | cutaneous leishmaniasis il-10 il-12 il-4 human matrix metalloproteinase-13 (mmp-13) |
| url | https://doi.org/10.4103/MJBL.MJBL_1202_23 |
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