Exacerbated ischemic brain damage in type 2 diabetes via methylglyoxal-mediated miR-148a-3p decline

Exacerbated ischemic brain damage in type 2 diabetes via methylglyoxal-mediated miR-148a-3p decline

Abstract Background Although microvascular dysfunction is a widespread phenomenon in type 2 diabetes (T2D) and is recognized as a main cause of T2D-aggravated ischemic stroke injury, the underlying mechanisms by which T2D-mediated exacerbation of cerebral damage after ischemic stroke is still largel...

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Bibliographic Details
Main Authors: Zhenguo Yang, Cheng Huang, Wenhui Huang, Chao Yan, Xueyi Wen, Di Hu, Hesong Xie, Kejing He, Chi Kwan Tsang, Keshen Li
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Medicine
Subjects:
Diabetic stroke
Blood-brain barrier
Methylglyoxal
MiR-148a-3p
SMAD2
Online Access:https://doi.org/10.1186/s12916-024-03768-3
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