Unveiling Smyd-2’s Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion

Unveiling Smyd-2’s Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion

SET and MYND Domain-Containing 2 (Smyd-2), a specific protein lysine methyltransferase (PKMT), influences both histones and non-histones. Its role in cerebral ischemia/reperfusion (CIR), particularly in ferroptosis—a regulated form of cell death driven by lipid peroxidation—remains poorly understood...

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Bibliographic Details
Main Authors: Daohang Liu, Yizhun Zhu
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
Smyd-2
Nrf-2
ischemic stroke
ferroptosis
lipid peroxidation
hinge and latch
Online Access:https://www.mdpi.com/2073-4409/13/23/1969
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