A non-canonical mechanism of GPCR activation

A non-canonical mechanism of GPCR activation

Abstract The goal of designing safer, more effective drugs has led to tremendous interest in molecular mechanisms through which ligands can precisely manipulate the signaling of G-protein-coupled receptors (GPCRs), the largest class of drug targets. Decades of research have led to the widely accepte...

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Main Authors: Alexander S. Powers, Aasma Khan, Joseph M. Paggi, Naomi R. Latorraca, Sarah Souza, Jerry Di Salvo, Jun Lu, Stephen M. Soisson, Jennifer M. Johnston, Adam B. Weinglass, Ron O. Dror
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54103-6
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https://doi.org/10.1038/s41467-024-54103-6

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