Preventive beneficial effects of cannabidiol in a reserpine-induced progressive model of parkinsonism

Preventive beneficial effects of cannabidiol in a reserpine-induced progressive model of parkinsonism

Introduction:Parkinson's disease (PD) is characterized by motor and non-motor symptoms such as tremors, difficulty in initiating movements, depression, and cognitive deficits. The pathophysiology of PD involves a gradual decrease in dopaminergic neurons in the substantia nigra, increased inflam...

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Main Authors: Alvaro C. Lima, Vinicius S. Bioni, Marcela S. Becegato, Ywlliane Meier, Débora M. G. Cunha, Natan A. Aguiar, Narriman Gonçalves, Fernanda F. Peres, Antônio W. Zuardi, Jaime E. C. Hallak, José A. Crippa, Soraya S. Smaili, Vanessa C. Abilio, Regina H. Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
Parkinson’s disease
cannabis
animal model
catalepsy
oral movements
tyrosine hydroxylase
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1539783/full
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