Amino acid T25 in the substrate-binding domain of SARS-CoV-2 nsp5 is involved in viral replication in the mouse lung.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 5 (nsp5) is a cysteine protease involved in viral replication and suppression of the host immune system. The substrate-binding domain of nsp5 is important for its protease activity. However, the relationship between...

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Bibliographic Details
Main Authors: Yoshiro Sugiura, Kenta Shimizu, Tatsuki Takahashi, Shiori Ueno, Haruka Tanigou, Sodbayasgalan Amarbayasgalan, Wataru Kamitani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0312800
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