In-frame germline TP53 variant impairs p53 oligomerization and predisposes to cancer

In-frame germline TP53 variant impairs p53 oligomerization and predisposes to cancer

Abstract Germline loss-of-function variants in TP53 cause Li–Fraumeni syndrome (LFS) characterized by an early onset of various cancer types including sarcomas, adrenocortical carcinoma, and breast cancer. The most common are mutations in the DNA binding domain of p53, but alterations in the oligome...

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Main Authors: Lucie Vanikova, Eva Machackova, Barbora Nemcova, Jana Soukupova, Silvia Petrezselyova, Klara Novakova, Marcela Zenatova, Sarka Pavlova, Petra Kleiblova, Zdenek Kleibl, Lenka Foretova, Libor Macurek
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
TP53
p53
Li Fraumeni syndrome
Cancer
Online Access:https://doi.org/10.1038/s41598-025-14684-8
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