Immunomodulatory properties of Giloy (Tinospora cordifolia) leaves and its applications in value-added products
In Ayurvedic texts, Giloy (Tinospora cordifolia) have been known as the most potent and important medicinal product. Giloy leaves have been used for centuries to cure various ailments and diseases in the human body. This review highlights that giloy leaves have immunomodulatory properties and can be...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024169794 |
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| author | Jyoti Singh Etika Saxena Anjali Raj Chaudhary Mandeep Kaur Molly Salotra Prasad Rasane Sawinder Kaur Sezai Ercisli Melekber Sulusoglu Durul Mehmet Ramazan Bozhuyuk Ahmet Hakan Urusan Riaz Ullah |
| author_facet | Jyoti Singh Etika Saxena Anjali Raj Chaudhary Mandeep Kaur Molly Salotra Prasad Rasane Sawinder Kaur Sezai Ercisli Melekber Sulusoglu Durul Mehmet Ramazan Bozhuyuk Ahmet Hakan Urusan Riaz Ullah |
| author_sort | Jyoti Singh |
| collection | DOAJ |
| description | In Ayurvedic texts, Giloy (Tinospora cordifolia) have been known as the most potent and important medicinal product. Giloy leaves have been used for centuries to cure various ailments and diseases in the human body. This review highlights that giloy leaves have immunomodulatory properties and can be used to develop functional food products. The current review focuses on the phytochemical composition of giloy leaves, and the mechanism for their immunomodulatory action highlighting specific pathways including NF-kB pathway and interleukin modulation. Giloy leaves possess antioxidant activity and induce apoptosis of cells in the immune response. Studies have shown the potential of incorporating giloy leaves into a wide range of value-added products, such as beverages, biscuits, and herbal formulations, to bridge traditional knowledge with modern functional food production. A comparison of traditional and modern giloy-based products demonstrates their benefits and drawbacks, showing that traditional techniques can be combined with modern scientific developments to improve medicinal efficacy. Although giloy leaves-based products show promising potential, further research is necessary to ascertain their effectiveness. |
| format | Article |
| id | doaj-art-4b30b710a7e34178a3d09220851570a0 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-4b30b710a7e34178a3d09220851570a02025-01-17T04:49:55ZengElsevierHeliyon2405-84402025-01-01111e40948Immunomodulatory properties of Giloy (Tinospora cordifolia) leaves and its applications in value-added productsJyoti Singh0Etika Saxena1Anjali Raj Chaudhary2Mandeep Kaur3Molly Salotra4Prasad Rasane5Sawinder Kaur6Sezai Ercisli7Melekber Sulusoglu Durul8Mehmet Ramazan Bozhuyuk9Ahmet Hakan Urusan10Riaz Ullah11Department of Food Technology and Nutrition, Lovely Professional University, Phagwara, Punjab, 144411, India; Corresponding author.Department of Food Technology and Nutrition, Lovely Professional University, Phagwara, Punjab, 144411, IndiaDepartment of Food Technology and Nutrition, Lovely Professional University, Phagwara, Punjab, 144411, IndiaDepartment of Food Technology and Nutrition, Lovely Professional University, Phagwara, Punjab, 144411, IndiaDepartment of Food Technology and Nutrition, Lovely Professional University, Phagwara, Punjab, 144411, IndiaDepartment of Food Technology and Nutrition, Lovely Professional University, Phagwara, Punjab, 144411, IndiaDepartment of Food Technology and Nutrition, Lovely Professional University, Phagwara, Punjab, 144411, IndiaDepartment of Horticulture, Faculty of Agriculture, Ataturk University, 25240, Erzurum, TurkiyeDepartment of Horticulture, Faculty of Agriculture, Kocaeli University, 41200, Kocaeli, TurkiyeDepartment of Horticulture, Faculty of Agriculture, Igdir University, 76100, Igdir, TurkiyeDepartment of Plant and Animal Science, Vocational School of Food, Agriculture and Animal Science, 12200, Bingol, TurkiyeDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaIn Ayurvedic texts, Giloy (Tinospora cordifolia) have been known as the most potent and important medicinal product. Giloy leaves have been used for centuries to cure various ailments and diseases in the human body. This review highlights that giloy leaves have immunomodulatory properties and can be used to develop functional food products. The current review focuses on the phytochemical composition of giloy leaves, and the mechanism for their immunomodulatory action highlighting specific pathways including NF-kB pathway and interleukin modulation. Giloy leaves possess antioxidant activity and induce apoptosis of cells in the immune response. Studies have shown the potential of incorporating giloy leaves into a wide range of value-added products, such as beverages, biscuits, and herbal formulations, to bridge traditional knowledge with modern functional food production. A comparison of traditional and modern giloy-based products demonstrates their benefits and drawbacks, showing that traditional techniques can be combined with modern scientific developments to improve medicinal efficacy. Although giloy leaves-based products show promising potential, further research is necessary to ascertain their effectiveness.http://www.sciencedirect.com/science/article/pii/S2405844024169794Giloy leaves (Tinospora cordifolia)ImmunomodulatoryFunctional foodPhytochemical compositionNF-κB pathwayInterleukin modulation |
| spellingShingle | Jyoti Singh Etika Saxena Anjali Raj Chaudhary Mandeep Kaur Molly Salotra Prasad Rasane Sawinder Kaur Sezai Ercisli Melekber Sulusoglu Durul Mehmet Ramazan Bozhuyuk Ahmet Hakan Urusan Riaz Ullah Immunomodulatory properties of Giloy (Tinospora cordifolia) leaves and its applications in value-added products Heliyon Giloy leaves (Tinospora cordifolia) Immunomodulatory Functional food Phytochemical composition NF-κB pathway Interleukin modulation |
| title | Immunomodulatory properties of Giloy (Tinospora cordifolia) leaves and its applications in value-added products |
| title_full | Immunomodulatory properties of Giloy (Tinospora cordifolia) leaves and its applications in value-added products |
| title_fullStr | Immunomodulatory properties of Giloy (Tinospora cordifolia) leaves and its applications in value-added products |
| title_full_unstemmed | Immunomodulatory properties of Giloy (Tinospora cordifolia) leaves and its applications in value-added products |
| title_short | Immunomodulatory properties of Giloy (Tinospora cordifolia) leaves and its applications in value-added products |
| title_sort | immunomodulatory properties of giloy tinospora cordifolia leaves and its applications in value added products |
| topic | Giloy leaves (Tinospora cordifolia) Immunomodulatory Functional food Phytochemical composition NF-κB pathway Interleukin modulation |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024169794 |
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