Sexual dimorphism of stress response and immune/ inflammatory reaction: the corticotropin releasing hormone perspective
This review higlghts key aspects of corticotropin releasing hormone (CRH) biology of potential relevance to the sexual dimorphism of the stress response and immune/inflammatory reaction, and introduces two important new concepts based on the regulatory potential of the human (h) CRH gene: (1) a prop...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1995-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935195000275 |
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| _version_ | 1841524537459474432 |
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| author | Nicholas V. Vamvakopoulos |
| author_facet | Nicholas V. Vamvakopoulos |
| author_sort | Nicholas V. Vamvakopoulos |
| collection | DOAJ |
| description | This review higlghts key aspects of corticotropin releasing hormone (CRH) biology of potential relevance to the sexual dimorphism of the stress response and immune/inflammatory reaction, and introduces two important new concepts based on the regulatory potential of the human (h) CRH gene: (1) a proposed mechanism to account for the tissue-specific antithetical responses of hCRH gene expression to glucocorticolds, that may also explain the frequently observed antithetical effects of chronic glucocorticoid administration in clinical practice and (2) a heuristic diagram to illustrate the proposed modulation of the stress response and immune/ inflammatory reaction by steroid hormones, from the perspective of the CRH system. |
| format | Article |
| id | doaj-art-4b239086395948609d6f2066d42ac843 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4b239086395948609d6f2066d42ac8432025-02-03T05:52:54ZengWileyMediators of Inflammation0962-93511466-18611995-01-014316317410.1155/S0962935195000275Sexual dimorphism of stress response and immune/ inflammatory reaction: the corticotropin releasing hormone perspectiveNicholas V. Vamvakopoulos0Department of Biology-Genetics, University of Thessaly Medical School, Larisa 412 22, GreeceThis review higlghts key aspects of corticotropin releasing hormone (CRH) biology of potential relevance to the sexual dimorphism of the stress response and immune/inflammatory reaction, and introduces two important new concepts based on the regulatory potential of the human (h) CRH gene: (1) a proposed mechanism to account for the tissue-specific antithetical responses of hCRH gene expression to glucocorticolds, that may also explain the frequently observed antithetical effects of chronic glucocorticoid administration in clinical practice and (2) a heuristic diagram to illustrate the proposed modulation of the stress response and immune/ inflammatory reaction by steroid hormones, from the perspective of the CRH system.http://dx.doi.org/10.1155/S0962935195000275 |
| spellingShingle | Nicholas V. Vamvakopoulos Sexual dimorphism of stress response and immune/ inflammatory reaction: the corticotropin releasing hormone perspective Mediators of Inflammation |
| title | Sexual dimorphism of stress response and immune/ inflammatory reaction: the corticotropin releasing hormone perspective |
| title_full | Sexual dimorphism of stress response and immune/ inflammatory reaction: the corticotropin releasing hormone perspective |
| title_fullStr | Sexual dimorphism of stress response and immune/ inflammatory reaction: the corticotropin releasing hormone perspective |
| title_full_unstemmed | Sexual dimorphism of stress response and immune/ inflammatory reaction: the corticotropin releasing hormone perspective |
| title_short | Sexual dimorphism of stress response and immune/ inflammatory reaction: the corticotropin releasing hormone perspective |
| title_sort | sexual dimorphism of stress response and immune inflammatory reaction the corticotropin releasing hormone perspective |
| url | http://dx.doi.org/10.1155/S0962935195000275 |
| work_keys_str_mv | AT nicholasvvamvakopoulos sexualdimorphismofstressresponseandimmuneinflammatoryreactionthecorticotropinreleasinghormoneperspective |