Carvacrol alleviates acrylamide-induced hepatotoxicity in rats: an experimental insights
<b>Aim: </b>This study aimed to investigate the protective effects of carvacrol (CRV) on rat liver against acrylamide (AA)-induced hepatotoxicity.<p> <b>Materials and Methods: </b>A total of 30 Wistar Albino rats were used in the study. Rats were divided into 4 groups:...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2023-12-01
|
| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1436 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841561404395487232 |
|---|---|
| author | Aysegul Bulut Goktug Senturk Durmus Hatipoglu Mehmet Burak Ates |
| author_facet | Aysegul Bulut Goktug Senturk Durmus Hatipoglu Mehmet Burak Ates |
| author_sort | Aysegul Bulut |
| collection | DOAJ |
| description | <b>Aim: </b>This study aimed to investigate the protective effects of carvacrol (CRV)
on rat liver against acrylamide (AA)-induced hepatotoxicity.<p>
<b>Materials and Methods: </b>A total of 30 Wistar Albino rats were used in the
study. Rats were divided into 4 groups: Control (n:6), CRV (n:8, 50 mg/kg/
day carvacrol, i.p), AA (n:8, 40 mg/kg/day acrylamide, gavage) and AA+CRV
(n:8, 40 mg/kg/day acrylamide, gavage + 50 mg/kg/day carvacrol i.p).
At the end of the 15-day study period, the rats, whose blood samples were
taken under anesthesia, were euthanized and necropsied. Liver function
tests were examined from serums. At the same time for histological analysis,
scoring, and hematoxylin-eosin staining, liver tissues were preserved in 10%
formaldehyde solution.<p>
<b>Results:</b> In microscopic examination, it was determined that AA causes
hydropic/vacuolar degeneration, fatty changes, necrosis/apoptosis, bile
duct proliferation, hepatic cord dissociation, congestion, megalocytosis and
mononuclear cell infiltration. Parallelly, AA raised the levels of ALP, AST,
and ALT. The inclusion of CRV to the diet improved histological structure
and liver function tests considerably. These results show that CRV has a
hepatoprotective effect by reducing AA-induced liver damage.<p>
<b>Conclusion: </b>This study showed that CRV attenuated AA-induced liver injury.
It is considered that its preventive effect against liver damage is due to its
antioxidant properties. However, more research is needed to determine the
specific mechanism at the molecular level and offer therapeutic management
suggestions. |
| format | Article |
| id | doaj-art-4b182f60ff3947f997764200e1e5db3d |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-4b182f60ff3947f997764200e1e5db3d2025-01-03T01:36:24ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532023-12-013941771841436Carvacrol alleviates acrylamide-induced hepatotoxicity in rats: an experimental insightsAysegul Bulut0Goktug Senturk1Durmus Hatipoglu2Mehmet Burak Ates3Selcuk University, Veterinary Faculty, Department of Pathology, Konya, TürkiyeAksaray University, Veterinary Faculty, Department of Physiology, Aksaray, TürkiyeSelcuk Univercity, Veterinary Faculty, Department of Physiology, Konya, TürkiyeSelcuk University, Veterinary Faculty, Department of Pathology, Konya, Türkiye<b>Aim: </b>This study aimed to investigate the protective effects of carvacrol (CRV) on rat liver against acrylamide (AA)-induced hepatotoxicity.<p> <b>Materials and Methods: </b>A total of 30 Wistar Albino rats were used in the study. Rats were divided into 4 groups: Control (n:6), CRV (n:8, 50 mg/kg/ day carvacrol, i.p), AA (n:8, 40 mg/kg/day acrylamide, gavage) and AA+CRV (n:8, 40 mg/kg/day acrylamide, gavage + 50 mg/kg/day carvacrol i.p). At the end of the 15-day study period, the rats, whose blood samples were taken under anesthesia, were euthanized and necropsied. Liver function tests were examined from serums. At the same time for histological analysis, scoring, and hematoxylin-eosin staining, liver tissues were preserved in 10% formaldehyde solution.<p> <b>Results:</b> In microscopic examination, it was determined that AA causes hydropic/vacuolar degeneration, fatty changes, necrosis/apoptosis, bile duct proliferation, hepatic cord dissociation, congestion, megalocytosis and mononuclear cell infiltration. Parallelly, AA raised the levels of ALP, AST, and ALT. The inclusion of CRV to the diet improved histological structure and liver function tests considerably. These results show that CRV has a hepatoprotective effect by reducing AA-induced liver damage.<p> <b>Conclusion: </b>This study showed that CRV attenuated AA-induced liver injury. It is considered that its preventive effect against liver damage is due to its antioxidant properties. However, more research is needed to determine the specific mechanism at the molecular level and offer therapeutic management suggestions.http://eurasianjvetsci.org/pdf.php3?id=1436antioxidantshepatoprotectiveliveroxidative stressthyme |
| spellingShingle | Aysegul Bulut Goktug Senturk Durmus Hatipoglu Mehmet Burak Ates Carvacrol alleviates acrylamide-induced hepatotoxicity in rats: an experimental insights Eurasian Journal of Veterinary Sciences antioxidants hepatoprotective liver oxidative stress thyme |
| title | Carvacrol alleviates acrylamide-induced hepatotoxicity in rats: an experimental insights |
| title_full | Carvacrol alleviates acrylamide-induced hepatotoxicity in rats: an experimental insights |
| title_fullStr | Carvacrol alleviates acrylamide-induced hepatotoxicity in rats: an experimental insights |
| title_full_unstemmed | Carvacrol alleviates acrylamide-induced hepatotoxicity in rats: an experimental insights |
| title_short | Carvacrol alleviates acrylamide-induced hepatotoxicity in rats: an experimental insights |
| title_sort | carvacrol alleviates acrylamide induced hepatotoxicity in rats an experimental insights |
| topic | antioxidants hepatoprotective liver oxidative stress thyme |
| url | http://eurasianjvetsci.org/pdf.php3?id=1436 |
| work_keys_str_mv | AT aysegulbulut carvacrolalleviatesacrylamideinducedhepatotoxicityinratsanexperimentalinsights AT goktugsenturk carvacrolalleviatesacrylamideinducedhepatotoxicityinratsanexperimentalinsights AT durmushatipoglu carvacrolalleviatesacrylamideinducedhepatotoxicityinratsanexperimentalinsights AT mehmetburakates carvacrolalleviatesacrylamideinducedhepatotoxicityinratsanexperimentalinsights |