Pandemic potential of the Nipah virus and public health strategies adopted during outbreaks: Lessons from Kerala, India.
Kerala, a south Indian state witnessed several outbreaks of Nipah encephalitis since 2018, a zoonotic viral disease with significant pandemic potential. This review highlights the relevance of surveillance and health system preparedness, infection control, early diagnosis and treatment with broad-sp...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLOS Global Public Health |
| Online Access: | https://doi.org/10.1371/journal.pgph.0003926 |
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| author | Thekkumkara Surendran Anish Reghukumar Aravind Chandni Radhakrishnan Nivedita Gupta Pragya D Yadav Jerin Jose Cherian Rima Sahay Shubin Chenayil Anoop Kumar A S Anitha Puduvail Moorkoth Ashadevi Velichapat Ramakrishnan Lathika Shamsudeen Moideen Sekhar Lukose Kuriakose Kalathil Joseph Reena Thomas Mathew |
| author_facet | Thekkumkara Surendran Anish Reghukumar Aravind Chandni Radhakrishnan Nivedita Gupta Pragya D Yadav Jerin Jose Cherian Rima Sahay Shubin Chenayil Anoop Kumar A S Anitha Puduvail Moorkoth Ashadevi Velichapat Ramakrishnan Lathika Shamsudeen Moideen Sekhar Lukose Kuriakose Kalathil Joseph Reena Thomas Mathew |
| author_sort | Thekkumkara Surendran Anish |
| collection | DOAJ |
| description | Kerala, a south Indian state witnessed several outbreaks of Nipah encephalitis since 2018, a zoonotic viral disease with significant pandemic potential. This review highlights the relevance of surveillance and health system preparedness, infection control, early diagnosis and treatment with broad-spectrum antivirals, environmental conservation, and community engagement in mitigating Nipah outbreaks. Additionally, it emphasises the importance of developing new biologicals and anti-viral drugs to combat the disease. The article discusses the available evidence on the spillover mechanisms, genetic attributes of the circulating virus, ecological factors, risk of hospital-based superspreading, treatment outcomes and successful strategies employed in Kerala in response to the recurrent Nipah outbreaks. |
| format | Article |
| id | doaj-art-4b0c5ef1528a4fb6b57b60cb2d2dd0e5 |
| institution | Kabale University |
| issn | 2767-3375 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Global Public Health |
| spelling | doaj-art-4b0c5ef1528a4fb6b57b60cb2d2dd0e52025-01-08T05:51:34ZengPublic Library of Science (PLoS)PLOS Global Public Health2767-33752024-01-01412e000392610.1371/journal.pgph.0003926Pandemic potential of the Nipah virus and public health strategies adopted during outbreaks: Lessons from Kerala, India.Thekkumkara Surendran AnishReghukumar AravindChandni RadhakrishnanNivedita GuptaPragya D YadavJerin Jose CherianRima SahayShubin ChenayilAnoop Kumar A SAnitha Puduvail MoorkothAshadeviVelichapat Ramakrishnan LathikaShamsudeen MoideenSekhar Lukose KuriakoseKalathil Joseph ReenaThomas MathewKerala, a south Indian state witnessed several outbreaks of Nipah encephalitis since 2018, a zoonotic viral disease with significant pandemic potential. This review highlights the relevance of surveillance and health system preparedness, infection control, early diagnosis and treatment with broad-spectrum antivirals, environmental conservation, and community engagement in mitigating Nipah outbreaks. Additionally, it emphasises the importance of developing new biologicals and anti-viral drugs to combat the disease. The article discusses the available evidence on the spillover mechanisms, genetic attributes of the circulating virus, ecological factors, risk of hospital-based superspreading, treatment outcomes and successful strategies employed in Kerala in response to the recurrent Nipah outbreaks.https://doi.org/10.1371/journal.pgph.0003926 |
| spellingShingle | Thekkumkara Surendran Anish Reghukumar Aravind Chandni Radhakrishnan Nivedita Gupta Pragya D Yadav Jerin Jose Cherian Rima Sahay Shubin Chenayil Anoop Kumar A S Anitha Puduvail Moorkoth Ashadevi Velichapat Ramakrishnan Lathika Shamsudeen Moideen Sekhar Lukose Kuriakose Kalathil Joseph Reena Thomas Mathew Pandemic potential of the Nipah virus and public health strategies adopted during outbreaks: Lessons from Kerala, India. PLOS Global Public Health |
| title | Pandemic potential of the Nipah virus and public health strategies adopted during outbreaks: Lessons from Kerala, India. |
| title_full | Pandemic potential of the Nipah virus and public health strategies adopted during outbreaks: Lessons from Kerala, India. |
| title_fullStr | Pandemic potential of the Nipah virus and public health strategies adopted during outbreaks: Lessons from Kerala, India. |
| title_full_unstemmed | Pandemic potential of the Nipah virus and public health strategies adopted during outbreaks: Lessons from Kerala, India. |
| title_short | Pandemic potential of the Nipah virus and public health strategies adopted during outbreaks: Lessons from Kerala, India. |
| title_sort | pandemic potential of the nipah virus and public health strategies adopted during outbreaks lessons from kerala india |
| url | https://doi.org/10.1371/journal.pgph.0003926 |
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