Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China
Background Autogenous tooth transplantation offers significant advantages and promising success rates for replacing non-retainable teeth. This study aimed to investigate the prognostic factors, especially the impact of root canal treatment (RCT), of autotransplanted teeth in an up-to-6-year follow-u...
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PeerJ Inc.
2025-01-01
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| author | Bangfeng Han Liu Liu Zhishen Jiang Li Ye Yubin Cao Jian Pan |
| author_facet | Bangfeng Han Liu Liu Zhishen Jiang Li Ye Yubin Cao Jian Pan |
| author_sort | Bangfeng Han |
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| description | Background Autogenous tooth transplantation offers significant advantages and promising success rates for replacing non-retainable teeth. This study aimed to investigate the prognostic factors, especially the impact of root canal treatment (RCT), of autotransplanted teeth in an up-to-6-year follow-up cohort of 167 teeth in Southern China. Methods We enrolled adult patients from the Southern Medical University-Shenzhen Stomatology Hospital between 2017 and 2023. Patients underwent autogenous tooth transplantation to replace non-retainable molars with upper or lower third molars with Moorrees tooth development stage ≥5. All surgical procedures were performed by an experienced surgeon. The included patients were followed up for 6~72 (median 28.5) months. Success, failure, and survival rate and prognostic factors were evaluated using univariable Kaplan-Meier, multivariable generalized linear regression, and multivariable COX regression analyses. Results The overall success rate is 97.6% with four unsuccessful cases. Herein, two of them were removed, leading to an overall survival rate of 98.8%. A total of 159 cases (95%) received RCT in 3 months. Univariable log-rank analysis showed that RCT (RR 0.109, 95%CI 0.010 to 1.202, P = 0.028) and site relationship between donor and receipt sites (RR 3.359, 95% CI [1.210–9.329], P = 0.020) were two significant prognostic factors of autotransplanted teeth. Multivariable generalized linear regression revealed that RCT is the only significant factor protecting the success rate of autotransplanted teeth (HR 0.003, 95% CI [0.000–0.249], P = 0.010). However, in the Cox regression model, the effects of RCT (HR 0.009, 95% CI [0.000–2.514], P = 0.101) did not reach statistical significance. Other factors did not demonstrate a significant impact in this cohort. These results supported that autogenous tooth transplantation is a viable alternative to conventional implant treatment with strict indications. Our findings underscore the importance of RCT in transplanted teeth with closed or semi-closed apices. Multi-center observational studies with larger sample size and extended follow-up duration may be needed to validate the conclusion. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-4b093fb95831442797cedf6ae9fdeb482025-01-11T15:05:16ZengPeerJ Inc.PeerJ2167-83592025-01-0113e1882410.7717/peerj.18824Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern ChinaBangfeng Han0Liu Liu1Zhishen Jiang2Li Ye3Yubin Cao4Jian Pan5Shenzhen Stomatological Hospital, Southern Medical University, Shenzhen, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaBackground Autogenous tooth transplantation offers significant advantages and promising success rates for replacing non-retainable teeth. This study aimed to investigate the prognostic factors, especially the impact of root canal treatment (RCT), of autotransplanted teeth in an up-to-6-year follow-up cohort of 167 teeth in Southern China. Methods We enrolled adult patients from the Southern Medical University-Shenzhen Stomatology Hospital between 2017 and 2023. Patients underwent autogenous tooth transplantation to replace non-retainable molars with upper or lower third molars with Moorrees tooth development stage ≥5. All surgical procedures were performed by an experienced surgeon. The included patients were followed up for 6~72 (median 28.5) months. Success, failure, and survival rate and prognostic factors were evaluated using univariable Kaplan-Meier, multivariable generalized linear regression, and multivariable COX regression analyses. Results The overall success rate is 97.6% with four unsuccessful cases. Herein, two of them were removed, leading to an overall survival rate of 98.8%. A total of 159 cases (95%) received RCT in 3 months. Univariable log-rank analysis showed that RCT (RR 0.109, 95%CI 0.010 to 1.202, P = 0.028) and site relationship between donor and receipt sites (RR 3.359, 95% CI [1.210–9.329], P = 0.020) were two significant prognostic factors of autotransplanted teeth. Multivariable generalized linear regression revealed that RCT is the only significant factor protecting the success rate of autotransplanted teeth (HR 0.003, 95% CI [0.000–0.249], P = 0.010). However, in the Cox regression model, the effects of RCT (HR 0.009, 95% CI [0.000–2.514], P = 0.101) did not reach statistical significance. Other factors did not demonstrate a significant impact in this cohort. These results supported that autogenous tooth transplantation is a viable alternative to conventional implant treatment with strict indications. Our findings underscore the importance of RCT in transplanted teeth with closed or semi-closed apices. Multi-center observational studies with larger sample size and extended follow-up duration may be needed to validate the conclusion.https://peerj.com/articles/18824.pdfOral surgeryDental autotransplantationImpacted teethRoot canal treatment |
| spellingShingle | Bangfeng Han Liu Liu Zhishen Jiang Li Ye Yubin Cao Jian Pan Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China PeerJ Oral surgery Dental autotransplantation Impacted teeth Root canal treatment |
| title | Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China |
| title_full | Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China |
| title_fullStr | Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China |
| title_full_unstemmed | Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China |
| title_short | Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China |
| title_sort | efficacy of root canal treatment for autotransplanted third molars a 6 year cohort study of 167 teeth in southern china |
| topic | Oral surgery Dental autotransplantation Impacted teeth Root canal treatment |
| url | https://peerj.com/articles/18824.pdf |
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