Mast cell mediated myofibroblast differentiation responsible for progression of oral submucous fibrosis
Myofibroblast from ally to adversary confirmed the role of myofibroblast in the progression of OSF. Several theories have been postulated regarding the etiopathogenesis of OSF, fibroblast being the key cell in causing fibrosis mediated by TGF. However, some fibroblasts have found to express features...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024000621 |
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| author | Mamatha GS Reddy Pradnya Kakodkar Vini Mehta |
| author_facet | Mamatha GS Reddy Pradnya Kakodkar Vini Mehta |
| author_sort | Mamatha GS Reddy |
| collection | DOAJ |
| description | Myofibroblast from ally to adversary confirmed the role of myofibroblast in the progression of OSF. Several theories have been postulated regarding the etiopathogenesis of OSF, fibroblast being the key cell in causing fibrosis mediated by TGF. However, some fibroblasts have found to express features of smooth muscle differentiation which are referred to as myofibroblasts. In OSMF, both mast cells and myofibroblasts are shown to increase. We wish to propose a hypothesis that mast cells demonstrated in OSF through its granular contents histamine and tryptase may contribute in differentiating fibroblasts to myofibroblasts which are responsible for the fibrosis occurrence in OSF. |
| format | Article |
| id | doaj-art-4aaa79d5b7264ca5af0aa234a1f7b1ca |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-4aaa79d5b7264ca5af0aa234a1f7b1ca2025-01-09T06:15:23ZengElsevierOral Oncology Reports2772-90602024-03-019100216Mast cell mediated myofibroblast differentiation responsible for progression of oral submucous fibrosisMamatha GS Reddy0Pradnya Kakodkar1Vini Mehta2Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, 411018, IndiaIndependent Research Consultant, Pune, Maharashtra, IndiaCorresponding author.; Department of Dental Research Cell, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, 411018, IndiaMyofibroblast from ally to adversary confirmed the role of myofibroblast in the progression of OSF. Several theories have been postulated regarding the etiopathogenesis of OSF, fibroblast being the key cell in causing fibrosis mediated by TGF. However, some fibroblasts have found to express features of smooth muscle differentiation which are referred to as myofibroblasts. In OSMF, both mast cells and myofibroblasts are shown to increase. We wish to propose a hypothesis that mast cells demonstrated in OSF through its granular contents histamine and tryptase may contribute in differentiating fibroblasts to myofibroblasts which are responsible for the fibrosis occurrence in OSF.http://www.sciencedirect.com/science/article/pii/S2772906024000621Mast cellsOral submucous fibrosisMyofibroblast |
| spellingShingle | Mamatha GS Reddy Pradnya Kakodkar Vini Mehta Mast cell mediated myofibroblast differentiation responsible for progression of oral submucous fibrosis Oral Oncology Reports Mast cells Oral submucous fibrosis Myofibroblast |
| title | Mast cell mediated myofibroblast differentiation responsible for progression of oral submucous fibrosis |
| title_full | Mast cell mediated myofibroblast differentiation responsible for progression of oral submucous fibrosis |
| title_fullStr | Mast cell mediated myofibroblast differentiation responsible for progression of oral submucous fibrosis |
| title_full_unstemmed | Mast cell mediated myofibroblast differentiation responsible for progression of oral submucous fibrosis |
| title_short | Mast cell mediated myofibroblast differentiation responsible for progression of oral submucous fibrosis |
| title_sort | mast cell mediated myofibroblast differentiation responsible for progression of oral submucous fibrosis |
| topic | Mast cells Oral submucous fibrosis Myofibroblast |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024000621 |
| work_keys_str_mv | AT mamathagsreddy mastcellmediatedmyofibroblastdifferentiationresponsibleforprogressionoforalsubmucousfibrosis AT pradnyakakodkar mastcellmediatedmyofibroblastdifferentiationresponsibleforprogressionoforalsubmucousfibrosis AT vinimehta mastcellmediatedmyofibroblastdifferentiationresponsibleforprogressionoforalsubmucousfibrosis |